875634-01-8

Basic information

• Product Name: 3-PyridinecarboxaMide, 5-[3-(2-Methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-diMethyl-
• Synonyms: 3-PyridinecarboxaMide, 5-[3-(2-Methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-diMethyl-;PPY A;5-[3-(2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethylpyridine-3-carboxamide
• CAS NO: 875634-01-8
• Molecular Formula: C22H20N4O2
• Molecular Weight: 372.4198
• Mol File: 875634-01-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-PyridinecarboxaMide, 5-[3-(2-Methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-diMethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-PyridinecarboxaMide, 5-[3-(2-Methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-diMethyl-(875634-01-8)
• EPA Substance Registry System: 3-PyridinecarboxaMide, 5-[3-(2-Methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-diMethyl-(875634-01-8)

Safety Data

• Hazardous Substances Data: 875634-01-8(Hazardous Substances Data)

Upstream product

• 20826-04-4 5-bromo-3-pyridinecarboxylic acid 
• 292170-96-8 5-bromo-N,N-dimethylnicotinamide 
• 875639-17-1 3-(2-methoxyphenyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine 
• 183208-35-7 5-bromo-1H-pyrrolo[2,3-b]pyridine 
• 875639-16-0 5-bromo-3-(2-methoxyphenyl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine 
• 875639-15-9 5-bromo-3-iodo-1-(4-methylbenzene-1-sulfonyl)-1H-pyrrolo[2,3-b]pyridine 
• 757978-18-0 3-iodo-5-bromo-1H-pyrrolo[2,3-b]-pyridine 
• 39620-02-5 5-bromonicotinoyl chloride 

Relevant articles and documents

Strategic Design of Catalytic Lysine-Targeting Reversible Covalent BCR-ABL Inhibitors**

Targeted covalent inhibitors have re-emerged as validated drugs to overcome acquired resistance in cancer treatment. Herein, by using a carbonyl boronic acid (CBA) warhead, we report the structure-based design of BCR-ABL inhibitors via reversible covalent targeting of the catalytic lysine with improved potency against both wild-type and mutant ABL kinases, especially ABLT315I bearing the gatekeeper residue mutation. We show the evolutionarily conserved lysine can be targeted selectively, and the selectivity depends largely on molecular recognition of the non-covalent pharmacophore in this class of inhibitors, probably due to the moderate reactivity of the warhead. We report the first co-crystal structures of covalent inhibitor-ABL kinase domain complexes, providing insights into the interaction of this warhead with the catalytic lysine. We also employed label-free mass spectrometry to evaluate off-targets of our compounds at proteome-wide level in different mammalian cells.

Pyrrolo-pyridine kinase modulators

The present invention provides novel pyrrolo-pyridine kinase modulators and methods of using the novel pyrrolo-pyridine kinase modulators to treat diseases mediated by kinase activity.