87597-54-4

Basic information

• Product Name: 3-(4-Ethoxy-phenyl)-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid amide
• Synonyms: 3-(4-Ethoxy-phenyl)-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid amide
• CAS NO: 87597-54-4
• Molecular Weight: 300.277
• Mol File: 87597-54-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(4-Ethoxy-phenyl)-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid amide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-Ethoxy-phenyl)-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid amide(87597-54-4)
• EPA Substance Registry System: 3-(4-Ethoxy-phenyl)-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid amide(87597-54-4)

Safety Data

• Hazardous Substances Data: 87597-54-4(Hazardous Substances Data)

Upstream product

• 7008-85-7 5-diazoimidazole-4-carboxamide 
• 32459-62-4 4-ethoxyphenyl isocyanate 

Downstream Products

• 4345-85-1 1-(4-ethoxy-phenyl)-3-phenyl urea 

Relevant articles and documents

Antitumor Imidazotetrazines. 1. Synthesis and Chemistry of 8-Carbamoyl-3-(2-chloroethyl)imidazo-1,2,3,5-tetrazin-4(3H)-one, a Novel Broad-Spectrum Antitumor Agent

Interaction of 5-diazoimidazole-4-carboxamide and alkyl and aryl isocyanates in the dark affords 8-carbamoyl-3-substituted-imidazo-1,2,3,5-tetrazin-4(3H)-ones.In cold methanol or ethanol, the 3-(2-chloroethyl) derivative 7a decomposes to afford 2-azahypoxanthine (14) and methyl and ethyl N-(2-chloroethyl)carbamates, respectively.Compound 7a has curative activity against L-1210 and P388 leukemia and may act as a prodrug modification of the acyclic triazene 5-imidazole-4-carboxamide (MCTIC), since it ring opens to form the triazene in aqueous sodium carbonate.