876-92-6

Basic information

• Product Name: 2-Phenyl-2H-pyrazole-3(4H)-one
• Synonyms: 1-Phenyl-1H-pyrazole-5(4H)-one;1-Phenyl-2-pyrazoline-5-one;2-Phenyl-2H-pyrazole-3(4H)-one;1-phenyl-1H-pyrazol-5(4H)-one;2-Phenyl-2,4-dihydro-3H-pyrazol-3-one;2,4-Dihydro-2-phenyl-3H-pyrazol-3-one;1-Phenyl-2-pyrazolin-5-one;1-Phenyl-5-pyrazolone
• CAS NO: 876-92-6
• Molecular Formula: C₉H₈N₂O
• Molecular Weight: 160.17
• Mol File: 876-92-6.mol
• Article Data: 7

Chemical Properties

• Melting Point: 118 °C
• Boiling Point: 261.8±23.0 °C(Predicted)
• Appearance: /
• Density: 1.20±0.1 g/cm3(Predicted)
• PKA: 2.13±0.50(Predicted)
• CAS DataBase Reference: 2-Phenyl-2H-pyrazole-3(4H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Phenyl-2H-pyrazole-3(4H)-one(876-92-6)
• EPA Substance Registry System: 2-Phenyl-2H-pyrazole-3(4H)-one(876-92-6)

Safety Data

• Hazardous Substances Data: 876-92-6(Hazardous Substances Data)

Usage

General Description

2-Phenyl-2H-pyrazole-3(4H)-one, also known as 4-phenyl-3-pyrazolone, is a chemical compound with the molecular formula C9H8N2O. It is a heterocyclic aromatic organic compound that is commonly used in the manufacturing of dye intermediates and pharmaceuticals. This chemical is a white to light yellow crystalline solid with a melting point of around 140-142°C. It is also known for its use as a chelating agent in analytical chemistry and as an intermediate in the synthesis of various pharmaceutical compounds. Additionally, 2-Phenyl-2H-pyrazole-3(4H)-one has gained attention for its potential biological and pharmacological activities, including anti-inflammatory and analgesic properties. Overall, this chemical plays an important role in various industrial and research applications.

Upstream product

• 100-63-0 phenylhydrazine 
• 706819-80-9 5-ethoxy-1-phenyl-1H-pyrazole-4-carboxylic acid ethyl ester 
• 25115-90-6 2,4-dihydro-2-phenyl-4-ethoxycarbonyl-3H-pyrazol-3-one 
• 88585-32-4 4-ethoxycarbonyl-1-phenyl-3-pyrazolin-5-one 
• 1694-31-1 tert-butyl acetoacetate 
• 539-74-2 Ethyl 3-bromopropionate 

Downstream Products

• 100881-37-6 4-(2-amino-phenylimino)-2-phenyl-2,4-dihydro-pyrazol-3-one 
• 1009083-60-6 5-(2-nitro-phenoxy)-1-phenyl-1H-pyrazole 
• 929569-07-3 1-phenylpyrazolo[4',3':5,6]pyrano[3,2-c]pyridin-4(1H)-one 
• 57135-04-3 3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carbaldehyde 
• 1334735-76-0 6-butyl-1-phenyl-1H-pyrazolo[4,3-c]pyridine 
• 1334735-75-9 1-phenyl-6-(3-thienyl)-1H-pyrazolo[4,3-c]pyridine 
• 1334735-72-6 1,6-diphenyl-1H-pyrazolo[4,3-c]pyridine 
• 1334735-54-4 5-hex-1-ynyl-1-phenyl-1H-pyrazole-4-carbaldehyde 
• 1334735-51-1 1-phenyl-5-(3-thienylethynyl)-1H-pyrazole-4-carbaldehyde 
• 1334735-50-0 1-phenyl-5-(phenylethynyl)-1H-pyrazole-4-carbaldehyde 
• 635288-46-9 (E)-1-(5-hydroxy-1-phenyl-(1H)-pyrazole-4-yl)-3-phenylprop-2-ene-1-one 

Relevant articles and documents

ACSS2 INHIBITORS AND METHODS OF USE THEREOF

The present invention relates to novel ACSS2 inhibitors having activity as anti-cancer therapy, treatment of alcoholism, and viral infection (e.g., CMV), composition and methods of preparation thereof, and uses thereof for treating viral infection, alcoho

5-Iodo-3-ethoxypyrazoles: An entry point to new chemical entities

Our program, which has focused on the preparation of new pyrazole derivatives, has led us to report here an original and simplified preparation of ethyl 3-ethoxy-lW-pyrazole-4-carboxylate. This is based on the reaction of hydrazine monohydrochloride and diethyl 2-(ethoxymethylene)malonate. Further transformations of this key compound allowed the preparation of the two possible iodinated isomers, namely, 3-ethoxy-4-iodo- and 3-ethoxy-5-iodo-1H-pyrazole. These compounds have opened the way to a quick access to many original pyrazole series. As an illustration, we report here on the selectivity of N-arylation, by using the Lam and Cham method, the C4- and C5-arylation of some of these 3-ethoxy-pyrazole derivatives by using the Suzuki-Miyaura reaction, and C5-benzylation reactions by means of the Negishi reaction. This was followed by hydrolysis of the ethoxy group, which led to the corresponding pyrazol-3-one derivatives. As a conclusion of this work, we conducted an investigation into the regiochemistry of the condensation between diethyl 2-(ethoxymethylene) malonate and the hydrochloride salts of methyl, benzyl, or phenyl hydrazine.

DRUGS COMPRISING COMBINATION OF ANTITHROMBOTIC AGENT WITH PYRAZOLONE DERIVATIVE

It is intended to provide drugs for treating and/or preventing ischemic diseases which are safe and have little side effects. Namely, drugs comprising a combination of an antithrombotic agent and a pyrazolone derivative defined in the description or its pharmaceutically acceptable salt.