876061-15-3

Basic information

• Product Name: 2-Propenoic acid, 3-[3,5-difluoro-2-[methyl[[(phenylmethyl)thio]acetyl]amino]phenyl]-, 1,1-dimethylethyl ester, (2E)-
• CAS NO: 876061-15-3
• Molecular Formula: C23H25F2NO3S
• Molecular Weight: 433.519
• Mol File: 876061-15-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 3-[3,5-difluoro-2-[methyl[[(phenylmethyl)thio]acetyl]amino]phenyl]-, 1,1-dimethylethyl ester, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 3-[3,5-difluoro-2-[methyl[[(phenylmethyl)thio]acetyl]amino]phenyl]-, 1,1-dimethylethyl ester, (2E)-(876061-15-3)
• EPA Substance Registry System: 2-Propenoic acid, 3-[3,5-difluoro-2-[methyl[[(phenylmethyl)thio]acetyl]amino]phenyl]-, 1,1-dimethylethyl ester, (2E)-(876061-15-3)

Safety Data

• Hazardous Substances Data: 876061-15-3(Hazardous Substances Data)

Upstream product

• 876061-25-5 2-bromo-N-(2-bromo-4,6-difluorophenyl)-N-methylacetamide 
• 876061-13-1 2-(benzylsulfanyl)-N-(2-bromo-4,6-difluorophenyl)-N-methylacetamide 
• 1663-39-4 tert-Butyl acrylate 

Downstream Products

• 876061-33-5 (E)-tert-butyl 3-(2-(2-(benzylsulfonyl)-N-methylacetamido)-3,5-difluorophenyl)acrylate 

Relevant articles and documents

Solid phase approaches to N-heterocycles using a sulfur linker cleaved by SmI2

A sulfur HASC (α-hetero-atom substituted carbonyl) linker has been utilized in solid-phase approaches to oxindoles and tetrahydroquinolones. The route to oxindoles employs the first Pummerer cyclizations on solid phase, whereas the route to tetrahydroquinolones involves a microwave-assisted Heck reaction followed by a Michael cyclization. In both cases, the linker is cleaved in a traceless fashion by electron transfer from samarium(II) iodide. The routes illustrate the compatibility of the linker system with a number of reaction types and its utility for library synthesis.