876066-53-4

Basic information

• Product Name: 6,7-Isoquinolinediol, 5,8-dichloro-2-[4-(4-chlorophenyl)-1-oxobutyl]-1,2,3,4-tetrahydro-
• CAS NO: 876066-53-4
• Molecular Formula: C19H18Cl3NO3
• Molecular Weight: 414.716
• Mol File: 876066-53-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6,7-Isoquinolinediol, 5,8-dichloro-2-[4-(4-chlorophenyl)-1-oxobutyl]-1,2,3,4-tetrahydro-(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7-Isoquinolinediol, 5,8-dichloro-2-[4-(4-chlorophenyl)-1-oxobutyl]-1,2,3,4-tetrahydro-(876066-53-4)
• EPA Substance Registry System: 6,7-Isoquinolinediol, 5,8-dichloro-2-[4-(4-chlorophenyl)-1-oxobutyl]-1,2,3,4-tetrahydro-(876066-53-4)

Safety Data

• Hazardous Substances Data: 876066-53-4(Hazardous Substances Data)

Upstream product

• 860437-58-7 5,8-dichloro-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline hydrobromide 
• 4619-18-5 4-(4-chlorophenyl)butanoic acid 

Relevant articles and documents

SAR studies of capsazepinoid bronchodilators 3: The thiourea part (coupling region) and the 2-(4-chlorophenyl)ethyl moiety (C-region)

Certain derivatives and analogues of capsazepine are potent in vitro inhibitors of bronchoconstriction in human small airways. During an investigation of the dependency of the potency on the structural features of the capsazepinoids in the thiourea moiety (coupling region) and the 2-(4-chlorophenyl)ethyl moiety (C-region), it was revealed that capsazepinoids with a thiourea or an amide link between the B-ring and the C-region in general have a good bronchorelaxing activity, while urea is a less attractive choice. Further, it was shown that 1,2,3,4-tetrahydroisoquinolines with a 2-(phenyl)ethyl derivative as the C-region are considerably more potent than those with an octyl group, while 2,3,4,5-tetrahydro-1H-2-benzazepines were found to be more insensitive to the nature of the C-region.