876289-18-8Relevant articles and documents
Synthesis, characterisation, supramolecular aggregation and biological activity of phosphine gold(I) complexes with monoanionic thiourea ligands
Henderson, William,Nicholson, Brian K.,Tiekink, Edward R.T.
, p. 204 - 214 (2008/10/09)
A series of phosphine gold(I) complexes containing monoanionic thiourea ligands has been synthesised by reaction of the appropriate precursor chloro complex, Ph3PAuCl, Cy3PAuCl, dppf(AuCl)2 [dppf = Fe(η5-C5H4PPh2)2] or dppe(AuCl)2 (dppe = Ph2PCH2CH 2PPh2) with the thiourea and Me3N base in methanol solution. The complexes have been fully characterised by elemental analysis, NMR spectrometry, electrospray mass spectrometry, and in several cases, by single-crystal X-ray diffraction studies. The crystallographic studies show that the ligands coordinate as a thiolate in each case with systematic variations in geometric parameters being readily ascribed to the influence of the N-bound substituents. In four of the structures, discernable supramolecular aggregation patterns are evident, leading to loosely associated dimers or chain motifs, the latter mediated by either Au?S, N-H?N or C-H?O interactions. Cytotoxicity data, against the P388 leukemia cell line, and anti-microbial data are also reported.