876343-82-7

Basic information

• Product Name: 5-Bromo-4-chloro-1H-pyrrolo[2,3-b]pyridine
• Synonyms: 5-Bromo-4-chloro-1H-pyrrolo[2,3-b]pyridine;1H-Pyrrolo[2,3-b]pyridine, 5-bromo-4-chloro-;5-Bromo-4-chloro-7-azaindole;4-bromo-5-chloro-1H-pyrrolo[2,3-b]pyridine;5-broMo-4-chloro-1H-pyrrolo[2;5-BroMo-4-chloro-7-azaind...
• CAS NO: 876343-82-7
• Molecular Formula: C₇H₄BrClN₂
• Molecular Weight: 231.48
• Product Categories: Heterocycle-Pyridine series
• Mol File: 876343-82-7.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• Density: 1.878 g/cm³
• Refractive Index: 1.73
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 12.02±0.40(Predicted)
• CAS DataBase Reference: 5-Bromo-4-chloro-1H-pyrrolo[2,3-b]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-4-chloro-1H-pyrrolo[2,3-b]pyridine(876343-82-7)
• EPA Substance Registry System: 5-Bromo-4-chloro-1H-pyrrolo[2,3-b]pyridine(876343-82-7)

Safety Data

• RIDADR: UN2811
• Hazardous Substances Data: 876343-82-7(Hazardous Substances Data)

Usage

General Description

5-Bromo-4-chloro-1H-pyrrolo[2,3-b]pyridine is a chemical compound with a molecular formula C7H4BrClN2. It is a heterocyclic compound containing a pyrrolopyridine core with bromine and chlorine substituents. 5-Bromo-4-chloro-1H-pyrrolo[2,3-b]pyridine has been studied for its potential use in pharmaceutical research and development due to its structural properties and potential biological activities. It may be used in the synthesis of pharmaceuticals and agrochemicals, as well as in the study of chemical reactions and mechanisms. As a result, it has garnered interest in the fields of organic chemistry, medicinal chemistry, and chemical biology.

InChI:InChI=1/C7H4BrClN2/c8-5-3-11-7-4(6(5)9)1-2-10-7/h1-3H,(H,10,11)

Upstream product

• 1092580-91-0 5-bromo-7-oxido-1H-pyrrolo[2,3-b]pyridin-7-ium 
• 183208-35-7 5-bromo-1H-pyrrolo[2,3-b]pyridine 
• 651744-48-8 4-chloro-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine 
• 55052-28-3 4-chloro-7-azaindole 
• 55052-24-9 1H-Pyrrolo[2,3-b]pyridine-7-oxide 
• 271-63-6 7-Azaindole 
• 685513-96-6 5-bromo-4-chloro-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine 

Downstream Products

• 1596337-81-3 5-bromo-4-chloro-1-[(4-methylphenyl)sulfonyl-1H-pyrrolo[2,3-b]pyridine] 

Relevant articles and documents

CHEMICAL COMPOUNDS

The present disclosure describes novel compounds, or their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and their medical uses. The compounds of the disclosure have activity as Janus kinase (JAK) inhibitors and are useful in the treatment or control of inflammation, auto-immune diseases, cancer, and other disorders and indications where modulation of JAK would be desirable. Also described herein are methods of treating inflammation, auto-immune diseases, cancer, and other conditions susceptible to inhibition of JAK by administering a compound herein described.

PYRROLO[2,3-B]PYRIDINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CANCER

The present application relates to a compound of Formula I, or a salt, hydrate or solvate thereof, as defined herein. The present compounds are found to have pharmacological effects, particularly at MRCK. Further provided are pharmaceutical compositions comprising said compounds. The present invention also relates to the use of these compounds as therapeutic agents, in particular, for the treatment and/or prevention of proliferative diseases, such as cancer.

PYRROLO[2,3-C]PYRIDINES AND RELATED ANALOGS AS LSD-1 INHIBITORS

The present disclosure provides compounds represented by Formula I and II: and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, X, W, Y, and Z are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I and II for use to treat a condition or disorder responsive to LSD1 inhibition such as cancer.