876343-86-1

Basic information

• Product Name: 1(2H)-Pyridinecarboxylic acid, 4-(5-broMo-4-chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)-3,6-dihydro-, 1,1-diMethylethyl ester
• Synonyms: 1(2H)-Pyridinecarboxylic acid, 4-(5-broMo-4-chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)-3,6-dihydro-, 1,1-diMethylethyl ester;tert-butyl 4-(5-bromo-4-chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)-5,6-dihydropyridine-1(2H)-carboxylate;UAJAJTDEJFDKKW-UHFFFAOYSA-N
• CAS NO: 876343-86-1
• Molecular Formula: C17H19BrClN3O2
• Molecular Weight: 412.70866
• Mol File: 876343-86-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1(2H)-Pyridinecarboxylic acid, 4-(5-broMo-4-chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)-3,6-dihydro-, 1,1-diMethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1(2H)-Pyridinecarboxylic acid, 4-(5-broMo-4-chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)-3,6-dihydro-, 1,1-diMethylethyl ester(876343-86-1)
• EPA Substance Registry System: 1(2H)-Pyridinecarboxylic acid, 4-(5-broMo-4-chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)-3,6-dihydro-, 1,1-diMethylethyl ester(876343-86-1)

Safety Data

• Hazardous Substances Data: 876343-86-1(Hazardous Substances Data)

Usage

Description

1(2H)-Pyridinecarboxylic acid, 4-(5-broMo-4-chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)-3,6-dihydro-, 1,1-diMethylethyl ester, also known as BMS-536924, is a carboxylic acid ester compound with potential applications in the pharmaceutical industry. It functions as a selective inhibitor of type I insulin-like growth factor receptor (IGF1R) and insulin receptor (IR), playing a crucial role in regulating cell growth, proliferation, and survival.

Uses

Used in Pharmaceutical Industry:
1(2H)-Pyridinecarboxylic acid, 4-(5-broMo-4-chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)-3,6-dihydro-, 1,1-diMethylethyl ester is used as a potential therapeutic agent for the treatment of various types of cancers. Its application is based on its ability to selectively block the activation and subsequent signaling pathways of IGF1R, which is involved in the regulation of cell growth, proliferation, and survival. Preclinical studies have shown promising anti-tumor activity, making BMS-536924 a potential candidate for further development as a targeted therapy for cancer treatment.

Upstream product

• 876343-87-2 5-bromo-4-chloro-2-iodo-1H-pyrrolo[2,3-b]pyridine 
• 375853-82-0 tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 

Relevant articles and documents

Pyrrolopyridine kinase inhibiting compounds

Compounds represented by Formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, are inhibitors of least one of the Abl, Aurora-A, Blk, c-Raf, cSRC, Src, PRK2, FGFR3, Flt3, Lck, Mek1, PDK-1, GSK3β, EGFR, p70S6K, BMX, SGK, CaMKII, Tie-2, IGF-1R, Ron, Met, and KDR kinases in animals, including humans, for the treatment and/or prevention of various diseases and conditions such as cancer.