87674-21-3

Basic information

• Product Name: Ethanone, 1-(3-fluoro-4-pyridinyl)- (9CI)
• Synonyms: Ethanone, 1-(3-fluoro-4-pyridinyl)- (9CI);1-(3-Fluoro-4-pyridinyl)ethanone;3-Fluoro-4-acetylpyridine;4-Acetyl-3-fluoropyridine;Ethanone, 1-(3-fluoro-4-pyridinyl)-
• CAS NO: 87674-21-3
• Molecular Formula: C7H6FNO
• Molecular Weight: 139.1270432
• Product Categories: ACETYLGROUP
• Mol File: 87674-21-3.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 199℃
• Flash Point: 74℃
• Appearance: /
• Density: 1.175
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 1.10±0.18(Predicted)
• CAS DataBase Reference: Ethanone, 1-(3-fluoro-4-pyridinyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(3-fluoro-4-pyridinyl)- (9CI)(87674-21-3)
• EPA Substance Registry System: Ethanone, 1-(3-fluoro-4-pyridinyl)- (9CI)(87674-21-3)

Safety Data

• Hazardous Substances Data: 87674-21-3(Hazardous Substances Data)

Usage

General Description

"Ethanone, 1-(3-fluoro-4-pyridinyl)- (9CI)" is a chemical compound that belongs to the class of ketones. It is also known as fluoropyridinyl ketone. Ethanone, 1-(3-fluoro-4-pyridinyl)- (9CI) consists of a pyridine ring with a fluorine atom attached at the 3rd position and a ketone group attached at the 1st position. It is primarily used as a building block in the synthesis of pharmaceuticals and agrochemicals. The compound has potential applications in the development of new drugs and agrochemical products. It is important to handle this compound with caution and follow proper safety procedures when working with it.

Upstream product

• 372-47-4 3-Fluoropyridine 
• 78191-00-1 N-Methoxy-N-methylacetamide 
• 1187669-49-3 3-fluoro-N-methyl-N-(methyloxy)-4-pyridinecarboxamide 
• 75-16-1 methylmagnesium bromide 
• 393-53-3 3-fluoroisonicotinic acid 
• 87674-15-5 4-(1-hydroxyethyl)-3-fluoropyridine 

Downstream Products

• 1187669-48-2 4-(3-fluoro-4-pyridinyl)-N-(3-methylphenyl)-1,3-thiazol-2-amine 

Relevant articles and documents

NOVEL GPR119 AGONIST COMPOUNDS

The present invention relates to novel compounds of formula (I), process for preparation of the same and composition comprising these compounds.

2,3,5-Trisubstituted pyridines as selective AKT inhibitors. Part II: Improved drug-like properties and kinase selectivity from azaindazoles

A novel series of AKT inhibitors containing 2,3,5-trisubstituted pyridines with novel azaindazoles as hinge binding elements are described. Among these, the 4,7-diazaindazole compound 2c has improved drug-like properties and kinase selectivity than those of indazole 1, and displays greater than 80% inhibition of GSK3β phosphorylation in a BT474 tumor xenograft model in mice.

HETEROARYL COMPOUNDS, COMPOSITIONS, AND METHODS OF USE IN CANCER TREATMENT

Provided herein are novel heteroaryl compounds, compositions comprising the compounds, and methods of treatment or prevention comprising administration of the compounds. The compounds are effective in the targeting of cells defective in the von Hippel-Lindau gene and in inducing autophagic cell death. The methods are directed to treating or preventing diseases such as cancer, and in particular cancers resulting from von Hippel-Lindau disease. The compounds of the invention may be administered in combination with another therapeutic agent.