876911-17-0

Basic information

• Product Name: Benzenebutanoic acid, 2-hydroxy-3-(hydroxymethyl)-, methyl ester
• CAS NO: 876911-17-0
• Molecular Formula: C12H16O4
• Molecular Weight: 224.257
• Mol File: 876911-17-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzenebutanoic acid, 2-hydroxy-3-(hydroxymethyl)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenebutanoic acid, 2-hydroxy-3-(hydroxymethyl)-, methyl ester(876911-17-0)
• EPA Substance Registry System: Benzenebutanoic acid, 2-hydroxy-3-(hydroxymethyl)-, methyl ester(876911-17-0)

Safety Data

• Hazardous Substances Data: 876911-17-0(Hazardous Substances Data)

Upstream product

• 876911-16-9 3-[3-(methoxycarbonyl)propyl]salicyl alcohol isopropylidene acetal 
• 28165-46-0 3-bromo-2-hydroxybenzyl alcohol 
• 876911-15-8 3-bromosalicyl alcohol isopropylidene acetal 
• 95-56-7 2-hydroxybromobenzene 

Relevant articles and documents

Second-generation cycloSal-d4TMP pronucleotides bearing esterase-cleavable sites - The "trapping" concept

An extension of the cycloSal-pronucleotide approach is presented. Attachment of an enzyme-cleavable ester/acylal group to the cycloSal-d4TMP triesters should allow these compounds to be trapped intracellularly after cleavage. The ester/acylal groups were introduced in the 3- or 5-position of the cycloSal ring system, and surprising differences were observed in hydrolysis studies in CEM cell extracts with respect to the ester/acylal moiety. While acetyl and levulinyl esters were readily cleaved, alkyl esters of cycloSal-d4TMP acids proved to be resistant to enzymatic cleavage. In contrast, AM-, POM- and POC-acylals were rapidly cleaved in the extracts, leading to cycloSal-d4TMP acids. The antiviral activity of the compounds against HIV is also presented. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.