876918-62-6

Basic information

• Product Name: 5-broMo-2-(tetrahydro-2H-pyran-4-yloxy)benzonitrile
• Synonyms: 5-broMo-2-(tetrahydro-2H-pyran-4-yloxy)benzonitrile;5-Bromo-2-(tetrahydro-pyran-4-yloxy)-benzonitrile
• CAS NO: 876918-62-6
• Molecular Formula: C₁₂H₁₂BrNO₂
• Molecular Weight: 282.13318
• Mol File: 876918-62-6.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-broMo-2-(tetrahydro-2H-pyran-4-yloxy)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 5-broMo-2-(tetrahydro-2H-pyran-4-yloxy)benzonitrile(876918-62-6)
• EPA Substance Registry System: 5-broMo-2-(tetrahydro-2H-pyran-4-yloxy)benzonitrile(876918-62-6)

Safety Data

• Hazardous Substances Data: 876918-62-6(Hazardous Substances Data)

Upstream product

• 2081-44-9 Tetrahydro-pyran-4-ol 
• 40530-18-5 5-bromo-2-hydroxybenzonitrile 
• 179897-89-3 5-Bromo-2-fluoro-benzonitrile 

Downstream Products

• 1292317-54-4 2-((tetrahydro-2H-pyran-4-yl)oxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile 
• 1893397-65-3 5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)-2-((tetrahydro-2H-pyran-4-yl)oxy)benzonitrile 

Relevant articles and documents

TBK/IKK INHIBITOR COMPOUNDS AND USES THEREOF

The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as TBK/IKKε inhibitors.

TANK-BINDING KINASE INHIBITOR COMPOUNDS

Compounds having the following formula (I) and methods of their use and preparation are disclosed:

BENZONITRILE DERIVATIVES AS KINASE INHIBITORS

Compounds of the formula I, in which R1, R2, X and Y have the meanings indicated in Claim 1, are inhibitors of TBK1 and IKKε and can be employed, inter alia, for the treatment of cancer and inflammatory diseases.