87694-59-5

Basic information

• Product Name: N-carbobenzoxy-L-pyroglutamyl-L-tryptophan ethyl ester
• CAS NO: 87694-59-5
• Molecular Weight: 477.517
• Mol File: 87694-59-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-carbobenzoxy-L-pyroglutamyl-L-tryptophan ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-carbobenzoxy-L-pyroglutamyl-L-tryptophan ethyl ester(87694-59-5)
• EPA Substance Registry System: N-carbobenzoxy-L-pyroglutamyl-L-tryptophan ethyl ester(87694-59-5)

Safety Data

• Hazardous Substances Data: 87694-59-5(Hazardous Substances Data)

Upstream product

• 98-79-3 L-Pyroglutamic acid 
• 501-53-1 benzyl chloroformate 
• 32159-21-0 Cbz-L-pGlu-OH 
• 2899-28-7 L-tryptophan ethyl ester hydrochloride 

Downstream Products

• 35937-24-7 L-pyroglutamyl-L-tryptophan 
• 87694-58-4 L-pyroglutamyl-L-tryptophan ethyl ester 

Relevant articles and documents

Synthesis, characterization and in vitro hydrolysis of L-pyroglutamyl-L-tryptophan derivatives as potential drug carriers

The condensation reaction of L-tryptophan with L-pyroglutamic acid or its N-carbobenzyloxy derivative in the presence of dicyclohexylcarbodiimide (DCC) afforded dipeptide molecules identified as L-pyroglutamyl-L-tryptophan derivatives. The synthesized dipeptide molecules offer a potentially useful means to obtain drug carriers and improve the poor uptake of drug molecules to the brain. The chemical hydrolysis characteristics in simulated gastro-intestinal juices are reported. No significant hydrolysis was observed.