87695-79-2Relevant articles and documents
Bicycloheteroarylamine compounds as ion channel ligands and uses thereof
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, (2008/06/13)
Amine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
Reactivity of 2-substituted 3-ethylsulfonylpyridines
Rouchaud, J.,Neus, O.,Moulard, C.
, p. 151 - 158 (2007/10/03)
2-Chloro-3-ethylsulfonylpyridine 6 was transformed by acidic or basic hydrolysis into 2-hydroxy-3-ethylsulfonylpyridine 4, which was in the OH form, i.e. without the 2-pyridone isomer.Diazomethane however transformed 4 into the mixture of the N- and O-methyl derivatives.Sodium sulfite reaction with 6 generated 2-sodiumsulfonate-3-ethylsulfonylpyridine 7.This did not react with SOCl2, and PCl5 transformed it into 6, no 2-sulfonylchloridepyridine being isolated.Potassium phthalimide reaction with 6 gave 2-phthalimido-3-ethylsulfonylpyridine 8', which was transformed by hydrazine into 2-amino-3-ethylsulfonylpyridine 8.This was not transformed by heating in acidic or basic aqueous solutions.In dilute acid solution, sodium nitrite transformed 8 into 4.In concentrated hydrochloric acid, the diazonium salt of 8 however was not formed. 2-(N-(4,6-Dimethoxy)pyrimidin-2-yl)amino-3-ethylsulfonylpyridine 3 in concentrated hydrochloric acid was transformed into 8, the intermediate N-(3-ethylsulfonyl-pyridine-2-yl)-guanidine 9 being isolated when the heating time was shorter.
