877-89-4

Basic information

• Product Name: 2,4,6-TRIMETHOXY-1,3,5-TRIAZINE
• Synonyms: 2,4,6-Trimethoxy-[1,3,5]-triazin;2,4,6-Trimethoxy-s-triazine;s-Triazine, 2,4,6-trimethoxy-;Trimethyl cyanurate;2,4,6-TRIMETHOXY-1,3,5-TRIAZINE;Methyl cyanurate
• CAS NO: 877-89-4
• Molecular Formula: C₆H₉N₃O₃
• Molecular Weight: 171.15
• EINECS: 212-896-2
• Product Categories: Heterocyclic Compounds;Building Blocks;Heterocyclic Building Blocks;Triazines
• Mol File: 877-89-4.mol
• Article Data: 21

Chemical Properties

• Melting Point: 135-137 °C(lit.)
• Boiling Point: 301.12°C (rough estimate)
• Flash Point: 103.1 °C
• Appearance: /
• Density: 1.3994 (rough estimate)
• Vapor Pressure: 0.00617mmHg at 25°C
• Refractive Index: 1.5800 (estimate)
• PKA: 1.80±0.10(Predicted)
• CAS DataBase Reference: 2,4,6-TRIMETHOXY-1,3,5-TRIAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,6-TRIMETHOXY-1,3,5-TRIAZINE(877-89-4)
• EPA Substance Registry System: 2,4,6-TRIMETHOXY-1,3,5-TRIAZINE(877-89-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 877-89-4(Hazardous Substances Data)

Usage

Uses

2,4,6-Trimethoxy-1,3,5-triazine was used to investigate the molecularly imprinted solid phase extraction (MISPE) for the isolation of melamine (ML) in food products.

General Description

2,4,6-Trimethoxy-1,3,5-triazine (TMT) is a triazine derivative. It exists in three different polymorphic forms: α-, β- and γ-. 2,4,6-Trimethoxy-1,3,5-triazine molecules are planar in all the three polymorphs. Polymorphic forms differ in the mode of packing of the molecules in the crystal. Kinetics and mechanism of the reaction of radiolytically produced hydrated electron with TMT using pulse and steady-state radiolysis techniques has been studied. TMT undergoes methyl transfer in the melt and in the solid-state, to afford, 2,4,6-trioxo-1,3,5-trimethylazine.

InChI:InChI=1/C6H9N3O3/c1-10-4-7-5(11-2)9-6(8-4)12-3/h1-3H3

Upstream product

• 506-68-3 bromocyane 
• 124-41-4 sodium methylate 
• 506-77-4 cyanogen chloride 
• 36335-90-7 2,4-dimethoxy-6-(methylthio)-1,3,5-triazine 
• 67-56-1 methanol 
• 100-21-0 terephthalic acid 
• 27257-90-5 2,4,6-tris(pyrazol-1-yl)-1,3,5-s-triazine 
• 1267550-97-9 C₅₇H₃₀Cl₃N₉O₆ 
• 675-14-9 trifluoro-[1,3,5]triazine 
• 624-83-9 methyl isocyanate 
• 74-88-4 methyl iodide 
• 108-77-0 1,3,5-trichloro-2,4,6-triazine 
• 109-99-9 tetrahydrofuran 
• 13320-09-7 1,3,5-Triazine-2,4,6-trisulfenyltrichloride 

Downstream Products

• 4107-73-7 4-amino-N-(4,6-dimethoxy-1,3,5-triazin-2-yl)benzenesulfonamide 
• 4255-67-8 N-acetyl-sulfanilic acid-(4,6-dimethoxy-[1,3,5]triazin-2-ylamide) 
• 16370-63-1 2-amino-4,6-dimethoxy-1,3,5-triazine 
• 1075-59-8 2-hydroxy-4,6-dimethoxy-1,3,5-triazine 
• 624-83-9 methyl isocyanate 
• 108-77-0 1,3,5-trichloro-2,4,6-triazine 
• 74-87-3 methylene chloride 
• 108-80-5 isocyanuric acid 
• 1075-59-8 2-hydroxy-4,6-dimethoxy-1,3,5-triazine 

Relevant articles and documents

NUCLEOPHILIC SUBSTITUTION REACTIONS OF 2,4,6-TRIS(TRINITROMETHYL)-1,3,5-TRIAZINE. 1. INTERACTION OF 2,4,6-TRIS(TRINITROMETHYL)-1,3,5-TRIAZINE WITH ALCOHOLS, DIOLS, AMMONIA AND SECONDARY AMINES

A study has been made of nucleophilic substitution reactions of 2,4,6-tris(trinitromethyl)-1,3,5-triazine with certain nucleophiles.The possibility of replacing one, two, or three trinitromethyl groups in this compound has been demonstrated.

Targeting the erythrocytic and liver stages of malaria parasites with s-triazine-based hybrids

A diversity-oriented library of s-triazine-based hybrids was screened for activity against the chloroquine-resistant Plasmodium falciparum W2 strain. The most striking result was sub-micromolar activity against cultured erythrocytic-stage parasites of hybrid molecules containing one or two 8-aminoquinoline moieties. These compounds were not clearly toxic to human cells. The most effective blood-schizontocidal s-triazine derivatives were then screened for activity against the liver stage of malaria parasites. The s-triazine hybrid containing two 8-aminoquinoline moieties and one chlorine atom emerged as the most potent against P. berghei liver-stage infection, active in the low nanomolar region, combined with good metabolic stability in rat liver microsomes. These results indicate that s-triazine-8-aminoquinoline-based hybrids are excellent starting points for lead optimization as dual-stage antimalarials.

Study of the Reactivities of Acid-Catalyzed O-Benzylating Reagents Based on Structural Isomers of 1,3,5-Triazine

We have demonstrated O-benzylating abilities of both 4,6-bis(benzyloxy)-1,3,5-triazin-2(1H)-one (DiBOT) and 6-(benzyloxy)-1,3,5-triazine-2,4(1H,3H)-dione (MonoBOT), which have been previously suggested as reaction intermediates of the acid-catalyzed benzylation of 2,4,6-tris(benzyloxy)-1,3,5-triazine (TriBOT). We studied the effect on the reactivity of acid-catalyzed O-benzylation caused by the isomeric core triazine structures in these compounds by carrying out a kinetic study and estimating relative basicities using model compounds. Since MonoBOT showed superior reactivity, 1,3,5-triazine-2,4(1H,3H)-dione is a promising core structure for acid-catalyzed alkylating reagents.