877061-66-0Relevant articles and documents
First Total Synthesis of Gliomasolide C and Formal Total Synthesis of Sch-725674
Seetharamsingh,Khairnar, Pankaj V.,Reddy, D. Srinivasa
, p. 290 - 296 (2016)
Syntheses of two 14-membered macrolides Sch-725674 and Gliomasolide C are described here. The first total synthesis of Gliomasolide C, the short synthesis of Sch-725674, and regioselective Wacker oxidation of internal olefin are the highlights of this disclosure. In addition, a key macrocycle with orthogonal functionalities was designed and synthesized on a gram scale for the generation of analogues.
A Pot-Economical Approach to the Total Synthesis of Sch-725674
Bodugam, Mahipal,Javed, Salim,Ganguly, Arghya,Torres, Jessica,Hanson, Paul R.
, p. 516 - 519 (2016)
A pot-economical total synthesis of antifungal Sch-725674, 1, is reported. The approach takes advantage of a number of one-pot, sequential transformations, including a phosphate tether-mediated one-pot, sequential RCM/CM/chemoselective hydrogenation proto
Enantioselective Modular Total Synthesis of Macrolides Sch725674 and C-4-epi-Sch725674
Sharma, Brijesh M.,Gontala, Arjun,Kumar, Pradeep
, p. 1215 - 1226 (2016/03/05)
The convergent total synthesis of Sch725674 has been accomplished by starting from (R)-1,2-epoxyheptane and assembling five modules in a highly stereoselective manner to give the final product in 6.6 % overall yield. The same strategy was extended to the
