877264-77-2

Basic information

• Product Name: 1-BOC-6-BROMO-INDAZOLE
• Synonyms: 1-BOC-6-BROMO-1H-INDAZOLE;6-Bromo-1H-indazole, N1-BOC protected;Tert-Butyl 6-broMo-1H-indazole-1-carboxylate C12H13BrN2O2;6-Bromo-1H-indazole-1-carboxylic acid tert-butyl ester;1H-Indazole-1-carboxylic acid, 6-broMo-, 1,1-diMethylethyl ester;tert-butyl 6-bromoindazole-1-carboxylate
• CAS NO: 877264-77-2
• Molecular Formula: C₁₂H₁₃BrN₂O₂
• Molecular Weight: 297.16
• Product Categories: Indazoles
• Mol File: 877264-77-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 377℃
• Flash Point: 182℃
• Appearance: /
• Density: 1.46
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-BOC-6-BROMO-INDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BOC-6-BROMO-INDAZOLE(877264-77-2)
• EPA Substance Registry System: 1-BOC-6-BROMO-INDAZOLE(877264-77-2)

Safety Data

• Hazardous Substances Data: 877264-77-2(Hazardous Substances Data)

Usage

General Description

1-BOC-6-Bromo-indazole is a chemical compound with the molecular formula C14H15BrN2O2. It is a derivative of indazole, a five-membered aromatic ring with two nitrogen atoms. The BOC group, which stands for tert-butyloxycarbonyl, is a protective group often used in organic synthesis to mask reactive functional groups. 1-BOC-6-BROMO-INDAZOLE is primarily used in pharmaceutical research and development as a building block for the synthesis of various biologically active molecules. Its bromine substituent also makes it a valuable synthetic intermediate for the preparation of diverse chemical compounds.

Upstream product

• 79762-54-2 6-bromo-1H-indazole 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 890839-29-9 1,1-dimethylethyl 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate 
• 1426095-38-6 N-{[(3R)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-4-(1H-indazol-6-yl)-N-(phenylmethyl)benzamide 
• 1426095-27-3 N-{[(3R)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-4-(1H-indazol-6-yl)-N-(1-methylethyl)benzamide 
• 1426095-23-9 N-{[(3R)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-N-ethyl-4-(1H-indazyl)benzamide 
• 1426095-02-4 N-{[(3S)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-4-(1H-indazol-6-yl)-N-methylbenzamide 
• 1301189-02-5 4-(1H-indazol-6-yl)benzaldehyde 

Relevant articles and documents

HEPARAN SULFATE BIOSYNTHESIS INHIBITORS FOR THE TREATMENT OF DISEASES

Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions in need of inhibition of heparan sulfate biosynthesis.

FATTY ACID SYNTHASE INHIBITORS

This invention relates to carboxamides and reverse carboxamides according to Formula (I) and the use of carboxamides and reverse carboxamides for the modulation, notably the inhibition of the activity or function of fatty acid synthase (FAS). Suitably, the present invention relates to the use of carboxamides and reverse carboxamides in the treatment of cancer.

BENZIMIDAZOLES AS FATTY ACID SYNTHASE INHIBITORS

This invention relates to the use of benzimidazole derivatives for the modulation, notably the inhibition of the activity or function of fatty acid synthase (FAS). Suitably, the present invention relates to the use of benzimidazoles in the treatment of cancer.