877269-03-9

Basic information

• Product Name: 13-cyclohexyl-6,7-dihydro-5H-pyrido[3',2':3,4]azepino[1,2-a]indole-10-carboxylic acid
• Synonyms: 13-cyclohexyl-6,7-dihydro-5H-pyrido[3',2':3,4]azepino[1,2-a]indole-10-carboxylic acid
• CAS NO: 877269-03-9
• Molecular Weight: 360.456
• Mol File: 877269-03-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 13-cyclohexyl-6,7-dihydro-5H-pyrido[3',2':3,4]azepino[1,2-a]indole-10-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 13-cyclohexyl-6,7-dihydro-5H-pyrido[3',2':3,4]azepino[1,2-a]indole-10-carboxylic acid(877269-03-9)
• EPA Substance Registry System: 13-cyclohexyl-6,7-dihydro-5H-pyrido[3',2':3,4]azepino[1,2-a]indole-10-carboxylic acid(877269-03-9)

Safety Data

• Hazardous Substances Data: 877269-03-9(Hazardous Substances Data)

Upstream product

• 799246-56-3 3-bromo-2-vinylpyridine 
• 877272-52-1 methyl 1-allyl-3-cyclohexyl-2-(2-vinylpyridin-3-yl)-1H-indole-6-carboxylate 
• 877272-37-2 methyl 3-cyclohexyl-2-(2-vinylpyridin-3-yl)-1H-indole-6-carboxylate 
• 13534-89-9 2,3-dibromopyridine 
• 863579-14-0 3-cyclohexyl-2-(4,4,5,5-tetramethyl-[1,3,2]-dioxaborolan-2-yl)-1H-indole-6-carboxylic acid methyl ester 
• 494799-19-8 methyl 2-bromo-3-cyclohexyl-1H-indole-6-carboxylate 
• 494799-18-7 methyl 3-cyclohexyl-1H-indole-6-carboxylate 

Relevant articles and documents

The synthesis of novel heteroaryl-fused 7,8,9,10-tetrahydro-6H-azepino[1,2- a]indoles, 4-oxo-2,3-dihydro-1H-[1,4]diazepino[1,7-a]indoles and 1,2,4,5-tetrahydro-[1,4]oxazepino[4,5-a]indoles. Effective inhibitors of HCV NS5B polymerase

Three synthetic approaches have been developed that allow efficient access to novel heteroaryl fused indole ring systems, including: 7,8,9,10-tetrahydro- 6H-azepino[1,2-a]indoles, 4-oxo-2,3-dihydro-1H-[1,4]diazepino[1,7-a]indoles and 1,2,4,5-tetrahydro-[1,4]oxazepino[4,5-a]indoles. Each strategy is fully exemplified and the relative merits and limitations of the approaches are discussed. The hepatitis C virus (HCV) non-structural 5B (NS5B) polymerase inhibitory activities of select examples from each molecular class are briefly presented.

Inhibitors of HCV replication

Indole compounds of Formula I are described. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. Different forms and compositions comprising the compounds are also described as well as methods of preparing the compounds.