87736-82-1 Usage
Description
3-(4-Methylphenyl)-3-(trifluoromethyl)diaziridine, with the CAS number 87736-82-1, is an off-white solid compound that is useful in organic synthesis. It is characterized by the presence of a diaziridine ring, a 4-methylphenyl group, and a trifluoromethyl group, which contribute to its unique chemical properties and reactivity.
Uses
Used in Organic Synthesis:
3-(4-Methylphenyl)-3-(trifluoromethyl)diaziridine is used as a synthetic intermediate for the preparation of various organic compounds. Its unique structure allows it to participate in a range of chemical reactions, such as cycloadditions, rearrangements, and cross-coupling reactions, enabling the synthesis of complex organic molecules with potential applications in pharmaceuticals, agrochemicals, and materials science.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3-(4-Methylphenyl)-3-(trifluoromethyl)diaziridine is used as a key building block for the development of novel drug candidates. Its ability to form diverse chemical entities makes it a valuable component in the design and synthesis of new therapeutic agents with improved pharmacological properties, such as enhanced potency, selectivity, and bioavailability.
Used in Agrochemical Industry:
3-(4-Methylphenyl)-3-(trifluoromethyl)diaziridine is also utilized in the agrochemical industry as a precursor for the synthesis of innovative agrochemicals, such as pesticides and herbicides. Its unique structural features can be exploited to create new molecules with improved efficacy, selectivity, and environmental compatibility, addressing the growing demand for sustainable agricultural practices.
Used in Materials Science:
In the field of materials science, 3-(4-Methylphenyl)-3-(trifluoromethyl)diaziridine is employed as a component in the development of advanced materials with specific properties, such as high thermal stability, chemical resistance, and unique optical or electronic characteristics. Its incorporation into polymers, coatings, and other materials can lead to the creation of novel materials with potential applications in various industries, including aerospace, automotive, and electronics.
Check Digit Verification of cas no
The CAS Registry Mumber 87736-82-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,7,7,3 and 6 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 87736-82:
(7*8)+(6*7)+(5*7)+(4*3)+(3*6)+(2*8)+(1*2)=181
181 % 10 = 1
So 87736-82-1 is a valid CAS Registry Number.
InChI:InChI=1/C9H9F3N2/c1-6-2-4-7(5-3-6)8(13-14-8)9(10,11)12/h2-5,13-14H,1H3
87736-82-1Relevant articles and documents
Photochemical Cyclopropenation of Alkynes with Diazirines as Carbene Precursors in Continuous Flow
Tanbouza, Nour,Carreras, Virginie,Ollevier, Thierry
supporting information, p. 5420 - 5424 (2021/07/26)
An efficient synthesis of 3-trifluoromethyl-3-aryl-cyclopropenes via the cyclopropenation reaction of alkynes with photolytically generated carbenes from diazirine compounds is described. This reaction is performed in continuous flow using readily available LEDs under mild reaction conditions. This new and efficient method describes the synthesis of 25 examples of 3-trifluoromethyl-3-aryl-cyclopropenes with yields up to 97%, achieved in continuous flow with a 5 min residence time. Control experiments highlighted that diazirines are more efficient than diazo compounds for this transformation.
Click-Addressable Cassette for Photoaffinity Labeling
Zhao, Bosheng,Burgess, Kevin
supporting information, p. 155 - 158 (2018/02/19)
A small molecule 1 was designed to contain an alkyne, a trifluoromethyl phenyldiazirine, and a free piperidine-NH for facile conjugation to protein binding ligands. This "cassette" 1 was synthesized via a relatively direct route involving only routine steps. In this proof-of-concept study, putative ligands for carbonic anhydrase IX and for TrkC were conjugated to 1. Photoaffinity labeling was performed using purified extracellular regions of both these protein-receptors, and using cells that express these receptors (isolation via a pull-down procedure), labeling of the protein was observed in all four experiments.
Synthesis of diazirine-based photoreactive saccharin derivatives for the photoaffinity labeling of gustatory receptors
Wang, Lei,Yoshida, Takuma,Muto, Yasuyuki,Murai, Yuta,Tachrim, Zetryana Puteri,Ishida, Akiko,Nakagawa, Shiori,Sakihama, Yasuko,Hashidoko, Yasuyuki,Masuda, Katsuyoshi,Hatanaka, Yasumaru,Hashimoto, Makoto
, p. 3129 - 3134 (2015/05/13)
Saccharin is one of the most common artificial sweeteners that has a bitter taste at high concentrations. Currently, there are no detailed functional analyses of these gustatory receptors. Therefore, we designed and synthesized photoreactive saccharin der
