87749-50-6

Basic information

• Product Name: Tetrabutylammonium fluoride trihydrate
• Synonyms: Tetrabutylammonium f;Tetrakis(but-1-yl)ammonium fluoride trihydrate 97%;TetrabutylaMMoniuM fluoride trihydrate, 99% 10GR;TetrabutylaMMoniuM fluoride trihydrate, 99% 50GR;TETRA-N-BUTYLAMMONIUM FLUORIDE TRIHYDRAT;Tetra(but-1-yl)ammonium fluoride trihydrate 97%;TBAF)TetrabutylaMMoniuM fluoride trihy;1-ButanaMiniuM,N,N,N-tributyl-, fluoride, hydrate (1:1:3)
• CAS NO: 87749-50-6
• Molecular Formula: C16H42FNO3
• Molecular Weight: 315.51
• EINECS: 207-057-2
• Product Categories: Pharmaceutical intermediates;Pyridines ,Heterocyclic Acids
• Mol File: 87749-50-6.mol
• Article Data: 0

Chemical Properties

• Melting Point: 62-63 °C(lit.)
• Flash Point: -17℃
• Appearance: White to slightly yellow/Crystalline Powder, Crystals and/or Chunks
• Storage Temp.: Store below +30°C.
• Water Solubility: SOLUBLE
• Sensitive: Hygroscopic
• BRN: 3761900
• CAS DataBase Reference: Tetrabutylammonium fluoride trihydrate(CAS DataBase Reference)
• NIST Chemistry Reference: Tetrabutylammonium fluoride trihydrate(87749-50-6)
• EPA Substance Registry System: Tetrabutylammonium fluoride trihydrate(87749-50-6)

Safety Data

• Hazard Codes: C,Xi
• Statements: 34-36/37/38
• Safety Statements: 26-36/37/39-45-26 37/39
• RIDADR: UN 1759 8/PG 1
• WGK Germany: 3
• F: 3-10
• TSCA: T
• HazardClass: 6.1
• PackingGroup: II
• Hazardous Substances Data: 87749-50-6(Hazardous Substances Data)

Usage

Description

Tetrabutylammonium fluoride trihydrate is a mild base that exists as white crystals or crystalline powder. It is commonly used in various organic reactions, including aldol-type condensation reactions, Michael-type reactions, and ring-opening reactions. Additionally, it serves as a promoter in cross-coupling reactions and cyclization of carbocycles and heterocycles.

Uses

Used in Organic Synthesis:
Tetrabutylammonium fluoride trihydrate is used as a reactant for the preparation of deprotecting agents in the synthesis of cellulose derivatives. This allows for the efficient production of cellulose-based materials with tailored properties.
Used in Peptide Synthesis:
In the biotechnology industry, Tetrabutylammonium fluoride trihydrate is used as a reactant for the synthesis of lipophilic peptides, which are essential for DNA transfections in vivo. This enables the development of novel gene therapy approaches and the study of gene function.
Used in Dehydrobromination Reactions:
Tetrabutylammonium fluoride trihydrate is utilized as a reactant in dehydrobromination reactions, a crucial process in the synthesis of various organic compounds. This application contributes to the advancement of organic chemistry and the development of new pharmaceuticals and materials.