878007-22-8

Basic information

• Product Name: (S)-(-)-4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxy-1-butyl]-3-(2-nitro-4-chlorophenoxymethyl)benzonitrile hydrochloride
• Synonyms: (S)-(-)-4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxy-1-butyl]-3-(2-nitro-4-chlorophenoxymethyl)benzonitrile hydrochloride
• CAS NO: 878007-22-8
• Molecular Weight: 534.415
• Mol File: 878007-22-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-(-)-4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxy-1-butyl]-3-(2-nitro-4-chlorophenoxymethyl)benzonitrile hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(-)-4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxy-1-butyl]-3-(2-nitro-4-chlorophenoxymethyl)benzonitrile hydrochloride(878007-22-8)
• EPA Substance Registry System: (S)-(-)-4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxy-1-butyl]-3-(2-nitro-4-chlorophenoxymethyl)benzonitrile hydrochloride(878007-22-8)

Safety Data

• Hazardous Substances Data: 878007-22-8(Hazardous Substances Data)

Upstream product

• 89-61-2 2,5-dichloronitrobenzene 
• 488787-59-3 (S)-(-)-4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxy-1-butyl]-3-(hydroxymethyl)benzonitrile 

Downstream Products

• 128196-01-0 escitalopram 
• 219861-08-2 escitalopram oxalate 

Relevant articles and documents

New process for preparing Citalopram and Escitalopram

The present invention provides a production method comprising the steps of: producing a compound of chemical formula 2 by esterifying a compound of chemical formula 3 with a compound of chemical formula 4; and synthesizing citalopram by cyclizing the compound of chemical formula 2 under the presence of a base. In the formulas, X is a leaving group, and Y is selected from H, NO_2, CF_3, CN, or Cl. According to the present invention, citalopram and escitalopram are produced at high purity and high yield.COPYRIGHT KIPO 2017