878160-13-5Relevant articles and documents
Introduction of a Methyl Group Curbs Metabolism of Pyrido[3,4- d]pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate N2-(2-Ethoxy-4-(4-methyl-4 H-1,2,4-triazol-3-yl)phenyl)-6-methyl- N
Woodward, Hannah L.,Innocenti, Paolo,Cheung, Kwai-Ming J.,Hayes, Angela,Roberts, Jennie,Henley, Alan T.,Faisal, Amir,Mak, Grace Wing-Yan,Box, Gary,Westwood, Isaac M.,Cronin, Nora,Carter, Michael,Valenti, Melanie,De Haven Brandon, Alexis,O'Fee, Lisa,Saville, Harry,Schmitt, Jessica,Burke, Rosemary,Broccatelli, Fabio,Van Montfort, Rob L. M.,Raynaud, Florence I.,Eccles, Suzanne A.,Linardopoulos, Spiros,Blagg, Julian,Hoelder, Swen
supporting information, p. 8226 - 8240 (2018/09/18)
Monopolar spindle 1 (MPS1) occupies a central role in mitosis and is one of the main components of the spindle assembly checkpoint. The MPS1 kinase is an attractive cancer target, and herein, we report the discovery of the clinical candidate BOS172722. Th
Woodward, Hannah L.,Innocenti, Paolo,Cheung, Kwai-Ming J.,Hayes, Angela,Roberts, Jennie,Henley, Alan T.,Faisal, Amir,Mak, Grace Wing-Yan,Box, Gary,Westwood, Isaac M.,Cronin, Nora,Carter, Michael,Valenti, Melanie,De Haven Brandon, Alexis,O'Fee, Lisa,Saville, Harry,Schmitt, Jessica,Burke, Rosemary,Broccatelli, Fabio,Van Montfort, Rob L. M.,Raynaud, Florence I.,Eccles, Suzanne A.,Linardopoulos, Spiros,Blagg, Julian,Hoelder, Swen
supporting information, p. 8226 - 8240 (2018/09/18)
Monopolar spindle 1 (MPS1) occupies a central role in mitosis and is one of the main components of the spindle assembly checkpoint. The MPS1 kinase is an attractive cancer target, and herein, we report the discovery of the clinical candidate BOS172722. Th
THIENOPYRIMIDINES FOR PHARMACEUTICAL COMPOSITIONS
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Page/Page column 119-120, (2010/11/25)
The present invention relates to novel pharmaceutical compositions of general formula (I) comprising thienopyrimidine compounds. Moreover, the present invention relates to the use of the thienopyrimidine compounds of the invention for the production of pharmaceutical compositions for the prophylaxis and/or treatment of diseases which can be influenced by the inhibition of the kinase activity of Mnk1 and/or Mnk2 (Mnk2a or Mnk2b) and/or variants thereof.