878194-93-5

Basic information

• Product Name: 2-CYANO-3-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE
• Synonyms: 2-CYANO-3-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE;2-CYANOPYRIDINE-3-BORONIC ACID, PINACOL ESTER;3-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)picolinonitrile;2-Pyridinecarbonitrile, 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-;3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-2-carbonitrile
• CAS NO: 878194-93-5
• Molecular Formula: C₁₂H₁₅BN₂O₂
• Molecular Weight: 230.07
• Mol File: 878194-93-5.mol
• Article Data: 3

Chemical Properties

• Melting Point: 58-61℃
• Boiling Point: 382.9 °C at 760 mmHg
• Flash Point: 185.4 °C
• Appearance: /
• Density: 1.1 g/cm³
• Vapor Pressure: 4.56E-06mmHg at 25°C
• Refractive Index: 1.506
• PKA: -0.33±0.12(Predicted)
• CAS DataBase Reference: 2-CYANO-3-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CYANO-3-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE(878194-93-5)
• EPA Substance Registry System: 2-CYANO-3-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE(878194-93-5)

Safety Data

• Hazardous Substances Data: 878194-93-5(Hazardous Substances Data)

Usage

Description

2-CYANO-3-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE is a pyridylborane derivative that has been evaluated for its kinase inhibitory activity. It is also used in immunodiagnostics and serves as an intermediate in the synthesis of various materials.

Uses

Used in Pharmaceutical Industry:
2-CYANO-3-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE is used as a kinase inhibitor for the development of potential therapeutic agents targeting specific kinases involved in various diseases.
Used in Diagnostics Industry:
2-CYANO-3-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE is used as a component in immunodiagnostics, aiding in the detection and analysis of specific biological markers.
Used as a Synthesis Intermediate:
2-CYANO-3-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE is utilized as an intermediate in the synthesis of various materials, contributing to the development of new compounds with potential applications in different industries.

InChI:InChI=1/C12H15BN2O2/c1-11(2)12(3,4)17-13(16-11)9-6-5-7-15-10(9)8-14/h5-7H,1-4H3

Upstream product

• 100-70-9 2-Cyanopyridine 
• 76-09-5 2,3-dimethyl-2,3-butane diol 
• 874290-88-7 (2-cyanopyridin-3-yl)boronic acid 

Downstream Products

• 932-35-4 3-hydroxypyridine-2-carbonitrile 
• 923012-55-9 7,8,9,10-tetrahydropyrido[2,3-c]-1,5-naphthyridine 
• 1452-77-3 pyridine-2-carboxylic acid amide 

Relevant articles and documents

MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE

Provided are IDO inhibitor compounds of Formula I and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and methods for their use in the prevention and/or treatment of diseases.

Synthesis of ortho-cyanopyridylboronic acids and esters toward cyano-functionalized bipyridines

This work describes the synthesis of ortho-cyanopyridylboronic acids and esters. Their reactivity with pyridine halides in the Suzuki cross-coupling reaction is evaluated and shows that the cyanopyridyl boronic esters appear to be more stable than their corresponding acids. These esters allowed us to synthesize new cyanobipyridine systems. Georg Thieme Verlag Stuttgart.