87860-35-3

Basic information

• Product Name: 1-Propanol, 2-phenoxy-, (S)-
• CAS NO: 87860-35-3
• Molecular Formula: C9H12O2
• Molecular Weight: 152.193
• Mol File: 87860-35-3.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: 1-Propanol, 2-phenoxy-, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanol, 2-phenoxy-, (S)-(87860-35-3)
• EPA Substance Registry System: 1-Propanol, 2-phenoxy-, (S)-(87860-35-3)

Safety Data

• Hazardous Substances Data: 87860-35-3(Hazardous Substances Data)

Usage

Usage

Intermediate in the production of pharmaceuticals and agrochemicals

Physical properties

Clear, colorless liquid; mild, floral odor; soluble in water

Applications

Solvent, fragrance ingredient in personal care products, building block for the synthesis of other chemicals

Toxicity

Low toxicity, generally regarded as safe for use in various applications.

Upstream product

• 4169-04-4 2-phenoxy-1-propanol 
• 108-95-2 phenol 
• 122-35-0 2-phenoxypropanoic acid chloride 
• 2065-24-9 methyl 2-phenoxypropanoate 
• 71159-33-6 (+/-)-2-phenoxy-1-propyl acetate 
• 1021327-16-1 N,N-diphenyl-2-phenoxypropionamide 
• 1213744-22-9 di(naphthalen-1-yl)methyl-2-phenoxypropanoate 
• 52687-81-7 2-phenoxypropionaldehyde 
• 105-38-4 vinyl propionate 
• 108-05-4 vinyl acetate 
• 885610-08-2 (S)-2-phenoxy-1-propyl acetate 
• 221310-60-7 (S)-(+)-(2-benzyloxy-1-methyl)ethyl 4-nitrobenzenesulfonate 
• 119233-39-5 (S)-(-)-(2-benzyloxy-1-methyl)ethyl 4-methyl-benzenesulfonate 
• 76671-57-3 (S)-(?)-ethyl 2-phenoxypropionate 

Downstream Products

• 97534-38-8 (S)-2-phenoxypropyl (R)-3,3,3-trifluoro-2-methoxy-2-phenylpropionate 

Relevant articles and documents

PYRIDIN-3-YL ACETIC ACID DERIVATIVES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION

Disclosed are compounds of Formula I, including pharmaceutically acceptable salts, pharmaceutical compositions comprising the compounds, methods for making the compounds and their use in inhibiting HIV integrase and treating those infected with HIV or AIDS.

Highly Enantioselective Hydrogenation of Amides via Dynamic Kinetic Resolution Under Low Pressure and Room Temperature

High-throughput screening and lab-scale optimization were combined to develop the catalytic system trans-RuCl2((S,S)-skewphos)((R,R)-dpen), 2-PrONa, and 2-PrOH. This system hydrogenates functionalized α-phenoxy and related amides at room temperature under 4 atm H2 pressure to give chiral alcohols with up to 99% yield and in greater than 99% enantiomeric excess via dynamic kinetic resolution.

CATALYSTS AND PROCESSES FOR THE HYDROGENATION OF AMIDES

There is provided a process for the reduction of one or more amide moieties in a compound comprising contacting the compound with hydrogen gas and a transition metal catalyst in the presence or absence of a base under conditions for the reduction an amide bond. The presently described processes can be performed at low catalyst loading using relatively mild temperature and pressures, and optionally, in the presence or absence of a base or high catalyst loadings using low temperatures and pressures and high loadings of base to effect dynamic kinetic resolution of achiral amides.