878812-87-4

Basic information

• Product Name: Benzenepropanoic acid, a-methyl-a-[[4-(1-methylethyl)phenyl]methoxy]-, ethyl ester
• CAS NO: 878812-87-4
• Molecular Formula: C22H28O3
• Molecular Weight: 340.463
• Mol File: 878812-87-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzenepropanoic acid, a-methyl-a-[[4-(1-methylethyl)phenyl]methoxy]-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanoic acid, a-methyl-a-[[4-(1-methylethyl)phenyl]methoxy]-, ethyl ester(878812-87-4)
• EPA Substance Registry System: Benzenepropanoic acid, a-methyl-a-[[4-(1-methylethyl)phenyl]methoxy]-, ethyl ester(878812-87-4)

Safety Data

• Hazardous Substances Data: 878812-87-4(Hazardous Substances Data)

Upstream product

• 103807-53-0 ethyl 2-bromo-2-methyl-3-phenylpropanoate 
• 536-60-7 cuminol 

Relevant articles and documents

A facile synthesis of 2-benzyloxy/2-(4-isopropylbenzyloxy)-2-methyl-3-(4- substituted phenyl)propanoic acid based insulin sensitizing agents: RSR 13-15 and PKR13-15

The title compounds (RSR13-15) and (PKR13-15) were prepared by the etherification of benzyl alcohol and 4-isopropylbenzyl alcohol respectively with ethyl-2-bromo-2-methyl-3-(4-substituted phenyl)propanoates in the presence of sodium hydride in THF followed by alkaline hydrolysis of the ethyl esters. The substituted propanoic acids used in this synthetic sequence were prepared by magnesium-methanol reduction of correspondingly substituted propenoic acids, which in turn were prepared via 'Perkin Reaction' of 4-substituted benzaldehydes with propanoic anhydride. The details of the synthetic sequence followed for the preparation of all these compounds having almost all the structural features required for a compound to act as a potent insulin sensitizing agent are reported. Birkhaeuser Boston 2004.