879219-19-9

Basic information

• Product Name: [(1R,2R)-2-Benzyloxy-1-(5-fluoro-2,3-dihydro-indol-1-ylmethyl)-propyl]-carbamic acid tert-butyl ester
• CAS NO: 879219-19-9
• Molecular Weight: 414.52
• Mol File: 879219-19-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [(1R,2R)-2-Benzyloxy-1-(5-fluoro-2,3-dihydro-indol-1-ylmethyl)-propyl]-carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [(1R,2R)-2-Benzyloxy-1-(5-fluoro-2,3-dihydro-indol-1-ylmethyl)-propyl]-carbamic acid tert-butyl ester(879219-19-9)
• EPA Substance Registry System: [(1R,2R)-2-Benzyloxy-1-(5-fluoro-2,3-dihydro-indol-1-ylmethyl)-propyl]-carbamic acid tert-butyl ester(879219-19-9)

Safety Data

• Hazardous Substances Data: 879219-19-9(Hazardous Substances Data)

Upstream product

• 79069-63-9 tert-butyl [(2R,3R)-3-(benzyloxy)-1-hydroxybutan-2-yl]carbamate 
• 15260-10-3 N-Boc-O-benzyl-L-threonine 
• 2343-22-8 5-fluoroindoline 
• 79069-55-9 tert-butyl [(2S,3R)-3-(benzyloxy)-1-oxobutan-2-yl]carbamate 

Downstream Products

• 769963-66-8 N-{(S)-1-[(1R,2R)-2-Benzyloxy-1-(5-fluoro-2,3-dihydro-indol-1-ylmethyl)-propylcarbamoyl]-3-cyclohexyl-propyl}-3-methoxy-benzamide 

Relevant articles and documents

Arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 2: Optimization of P1 and N-aryl

A systematic study of anilines led to the discovery of a metabolically robust fluoroindoline replacement for the alkoxy aniline toxicophore in 1. Investigations of the P1 pocket resulted in the discovery of a wide tolerance of functionality leading to the discovery of 11 as a potent and selective inhibitor of cathepsin S.