88016-84-6

Basic information

• Product Name: 4-benzyloxy-3-methoxy-1,3,5⁽¹⁰⁾-estratrien-17-one
• CAS NO: 88016-84-6
• Molecular Weight: 390.522
• Mol File: 88016-84-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-benzyloxy-3-methoxy-1,3,5⁽¹⁰⁾-estratrien-17-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-benzyloxy-3-methoxy-1,3,5⁽¹⁰⁾-estratrien-17-one(88016-84-6)
• EPA Substance Registry System: 4-benzyloxy-3-methoxy-1,3,5⁽¹⁰⁾-estratrien-17-one(88016-84-6)

Safety Data

• Hazardous Substances Data: 88016-84-6(Hazardous Substances Data)

Upstream product

• 100-44-7 benzyl chloride 
• 3131-23-5 4-hydroxyestrone 
• 186581-53-3 diazomethane 
• 88016-81-3 4-benzyloxy-3-hydroxy-1,3,5⁽¹⁰⁾-estratrien-17-one 

Downstream Products

• 5976-62-5 3-methoxy-4-hydroxy-1,3,5 ⁽¹⁰⁾-estratrien-17-one 

Relevant articles and documents

Methylation of catechol estrogen with diazomethane

Dynamic aspects of methylation of catechol estrogen with diazomethane were investigated by means of thin-layer chromatography. The methylation rate of the hydroxyl group at the C-3 position was almost the same as that of the C-2 hydroxyl group in the reaction of 2-hydroxyestrogen, and 2-3 times that of the C-4 hydroxyl group in the reaction of 4-hydroxyestrogen. In these experiments, the maximum yields of 2-methoxyestrone, 2-hydroxyestrone 3-methyl ether, 4-methoxyesterone and 4-hydroxyesterone 3-methyl ether were 32, 39, 13, and 70%, respectively. In addition, demethylation of catechol estrogen dimethyl ethers with boron tribromide and synthesis of 4-hydroxyestrone monomethyl ethers are described.