880335-30-8

Basic information

• Product Name: 1-Piperidinecarboxylic acid, 4-hydroxy-4-[methyl(phenylmethoxy)phosphinyl]-, phenylmethyl ester
• CAS NO: 880335-30-8
• Molecular Formula: C21H26NO5P
• Molecular Weight: 403.415
• Mol File: 880335-30-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-Piperidinecarboxylic acid, 4-hydroxy-4-[methyl(phenylmethoxy)phosphinyl]-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperidinecarboxylic acid, 4-hydroxy-4-[methyl(phenylmethoxy)phosphinyl]-, phenylmethyl ester(880335-30-8)
• EPA Substance Registry System: 1-Piperidinecarboxylic acid, 4-hydroxy-4-[methyl(phenylmethoxy)phosphinyl]-, phenylmethyl ester(880335-30-8)

Safety Data

• Hazardous Substances Data: 880335-30-8(Hazardous Substances Data)

Upstream product

• 18108-16-2 benzyl hypophosphite 
• 80902-08-5 methyl-o-benzylphosphinic acid 
• 19099-93-5 benzyl 4-oxo-1-piperidinecarboxylate 

Relevant articles and documents

Direct monoalkylation of alkyl phosphinates to access H-phosphinic acid esters

Simple alkyl phosphinates prepared by the silicate esterification method can be alkylated under Barbier-like conditions with butyl lithium at -78 °C followed by warming to room temperature. The method is limited to the more reactive electrophile such as allylic bromides and alkyl iodides. With these electrophiles good yields of H-phosphinic acid esters are generally obtained in a straightforward manner. Georg Thieme Verlag Stuttgart.