88094-35-3

Basic information

• Product Name: 3(2H)-Pyridazinone,4-chloro-2-(1,1-dimethylethyl)-5-[[4-(1,1-dimethylethyl)phenyl]methoxy]-
• CAS NO: 88094-35-3
• Molecular Formula: C19H25ClN2O2
• Molecular Weight: 348.873
• Mol File: 88094-35-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3(2H)-Pyridazinone,4-chloro-2-(1,1-dimethylethyl)-5-[[4-(1,1-dimethylethyl)phenyl]methoxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: 3(2H)-Pyridazinone,4-chloro-2-(1,1-dimethylethyl)-5-[[4-(1,1-dimethylethyl)phenyl]methoxy]-(88094-35-3)
• EPA Substance Registry System: 3(2H)-Pyridazinone,4-chloro-2-(1,1-dimethylethyl)-5-[[4-(1,1-dimethylethyl)phenyl]methoxy]-(88094-35-3)

Safety Data

• Hazardous Substances Data: 88094-35-3(Hazardous Substances Data)

Upstream product

• 877-65-6 p-tert-butylbenzyl alcohol 
• 84956-71-8 2-tert-butyl-4,5-dichloro-2H-pyridazin-3-one 

Relevant articles and documents

Synthesis and biological evaluation of pyridazinone analogues as potential cardiac positron emission tomography tracers

A series of fluorinated pyridazinone derivatives with IC50 values ranging from 8 to 4000 nM for the mitochondrial complex 1 (MC1) have been prepared. Structure-activity relationship (SAR) assessment indicated preference of the fluorine label to be incorporated on an alkyl side chain rather than directly on the pyridazinone moiety. Tissue distribution studies of a series of analogues ([18F] 22-28) in Sprague-Dawley (SD) rats identified [ 18F]27 as the most promising radiotracer with high uptake in cardiac tissue (3.41%ID/g; 30 min post injection) in addition to favorable heart to nontarget organ distribution ratios. MicroPET images of SD rats and nonhuman primates after [18F]27 administration allowed easy assessment of the myocardium through 60 min with minimal lung or liver interference.