881-95-8 Usage
Description
DL-M-O-METHYLEPINEPHRINE HYDROCHLORIDE is a metabolite of Epinephrine (E588585) and a naturally occurring derivative of Epinephrine. It is found in urine and certain tissues and exhibits off-white to pale yellow solid chemical properties.
Uses
Used in Pharmaceutical Industry:
DL-M-O-METHYLEPINEPHRINE HYDROCHLORIDE is used as an active pharmaceutical ingredient for the development of medications targeting various medical conditions. Its presence as a metabolite of Epinephrine suggests potential applications in treatments related to the sympathetic nervous system and its effects on the body.
Used in Research Applications:
DL-M-O-METHYLEPINEPHRINE HYDROCHLORIDE serves as a valuable research compound for studying the metabolism, pharmacokinetics, and pharmacodynamics of Epinephrine and its derivatives. It can be utilized in laboratory experiments to investigate the mechanisms of action and potential therapeutic benefits in various physiological and pathological processes.
Used in Diagnostic Applications:
As a metabolite of Epinephrine, DL-M-O-METHYLEPINEPHRINE HYDROCHLORIDE can be employed in diagnostic assays and tests to monitor the levels of Epinephrine and its metabolites in biological samples. This can aid in the assessment of certain medical conditions, treatment efficacy, and individual responses to medications.
Used in Analytical Chemistry:
The chemical properties of DL-M-O-METHYLEPINEPHRINE HYDROCHLORIDE, being an off-white to pale yellow solid, make it suitable for use in analytical chemistry techniques such as high-performance liquid chromatography (HPLC), mass spectrometry, and other methods for the identification, quantification, and quality control of related compounds in pharmaceutical formulations and biological samples.
Biochem/physiol Actions
Metanephrine is an endogenous metabolite of ephinephrine, formed by catechol-O-methyl transferase activity. It is best known as a biomarker for cancers, as levels of free metanephrine are used to diagnose pheochromocytoma. Metanephrine was previously thought to be biologically inactive, but it is a more potent agonist at Trace amine associated receptor TAAR1 than either epinephrine or norepinephrine. Trace amine associated receptors (TAARs) are recently discovered GPCRs that are activated by endogenous trace amines (tyramine, tryptamine, synephrine, octopamine, β-phenylethylamine), which are chemically similar to monoaminergic neurotransmitters (epinephrine, norepinephrine, dopamine). Trace amines and TAARs are expressed in brain and are implicated in modulation of monoaminergic neurotransmission.
Check Digit Verification of cas no
The CAS Registry Mumber 881-95-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 8,8 and 1 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 881-95:
(5*8)+(4*8)+(3*1)+(2*9)+(1*5)=98
98 % 10 = 8
So 881-95-8 is a valid CAS Registry Number.
InChI:InChI=1/C10H15NO3.ClH/c1-11-6-9(13)7-3-4-8(12)10(5-7)14-2;/h3-5,9,11-13H,6H2,1-2H3;1H
881-95-8Relevant articles and documents
SYNTHESIS OF 3-O-METHYLATED DERIVATIVES OF CATECHOLAMINES
Kulikov, S. V.,Samartsev, M. A.
, p. 280 - 288 (2007/10/02)
3-O-Methylated catecholamines, used in the radioenzyme method for the analysis of catecholamines in blood, were synthesized. The optimum conditions for the production of both the intermediate and the final products were determined. By the use of tetrabutylammonium bromide in the condensation of nitromethane with O-benzylvanilin it is possible to obtain a high yield of 1-(3-methoxy-4-benzyloxyphenyl)-2-nitroethanol. The latter is easily transformed at a palladium catalyst into methylnoradrenaline by reduction with ammonium formate. The reduction of 1-(3-methoxy-4-benzyloxyphenyl)-2-nitroethylene with hydrogen or its donors at a palladium catalyst takes place significantly more readily in the presence of ferric chloride.