88105-65-1

Basic information

• Product Name: L-Proline, 1-(phenylacetyl)-, phenylmethyl ester
• CAS NO: 88105-65-1
• Molecular Formula: C20H21NO3
• Molecular Weight: 323.392
• Mol File: 88105-65-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: L-Proline, 1-(phenylacetyl)-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Proline, 1-(phenylacetyl)-, phenylmethyl ester(88105-65-1)
• EPA Substance Registry System: L-Proline, 1-(phenylacetyl)-, phenylmethyl ester(88105-65-1)

Safety Data

• Hazardous Substances Data: 88105-65-1(Hazardous Substances Data)

Upstream product

• 103-82-2 phenylacetic acid 
• 16652-71-4 benzyl (2S)-2-pyrrolidinecarboxylate hydrochloride 
• 103-80-0 phenylacetyl chloride 
• 41324-66-7 H-Pro-OBzl 

Downstream Products

• 88105-66-2 N-(phenylacetyl)-L-prolyl-DL-α-methylphenylalanyl-N^ω-nitro-L-arginine methyl ester 
• 88106-02-9 N-(phenylacetyl)-L-prolyl-DL-α-methylphenylalanyl-N^ω-nitro-L-arginine 
• 88084-32-6 N-(phenylacetyl)-L-prolyl-DL-α-methylphenylalanyl-L-arginine 
• 92010-23-6 (S)-1-Phenylacetyl-pyrrolidine-2-carboxylic acid 2-benzyloxycarbonyl-phenyl ester 
• 92010-24-7 (S)-1-Phenylacetyl-pyrrolidine-2-carboxylic acid 2-carboxy-phenyl ester 
• 2752-38-7 (S)-1-(2-phenylacetyl)pyrrolidine-2-carboxylic acid 

Relevant articles and documents

PS-IIDQ: a supported coupling reagent for efficient and general amide bond formation

Polystyrene-IIDQ, a polymer-supported coupling reagent, was synthesized in three steps from Merrifield resin in 86% overall conversion. This reagent efficiently coupled carboxylic acids to amines in good yields and high purities, required no pre-activation step, and was tolerant of the order of reagent addition. PS-IIDQ was observed to be more efficient than polymer-supported carbodiimides (PS-EDC and PS-DCC) and gave higher yields than HATU for general amide bond formation, including the coupling of anilines and hindered substrates. When evaluated with five carboxylic acids and nine amines (including anilines and secondary amines) PS-IIDQ gave an average isolated yield of 73%.

Design, synthesis, and testing of potential antisickling agents. 5. Disubstituted benzoic acids designed for the donor site and proline salicylates designed for the acceptor site

This paper reports the discovery of a new class of potent antigelling agents. The new compounds, disubstituted benzoic acid derivatives, were designed by using molecular modeling experiments. These molecules contain functional groups positioned to interac