88122-95-6 Usage
Description
3-Hydroxy-4-sulfobenzoic Acid is an organic compound characterized by the presence of a hydroxyl and a sulfonic acid group attached to a benzene ring. It exhibits acidic properties and is soluble in water. This chemical compound is known for its role in the synthesis of various pharmaceuticals and has potential applications in different industries.
Uses
Used in Pharmaceutical Industry:
3-Hydroxy-4-sulfobenzoic Acid is used as a key intermediate in the synthesis of arginine vasopressin V2 receptor antagonist SR-121463. This antagonist has potential therapeutic applications in the treatment of conditions such as diabetes insipidus and heart failure, as it helps regulate water balance in the body and improves cardiovascular function.
In addition to its role in the synthesis of SR-121463, 3-Hydroxy-4-sulfobenzoic Acid may also have potential applications in the development of other pharmaceutical compounds, given its unique chemical structure and properties. Its ability to form salts and complexes with various ions and molecules could make it a valuable component in the design of new drugs and drug delivery systems.
Check Digit Verification of cas no
The CAS Registry Mumber 88122-95-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,8,1,2 and 2 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 88122-95:
(7*8)+(6*8)+(5*1)+(4*2)+(3*2)+(2*9)+(1*5)=146
146 % 10 = 6
So 88122-95-6 is a valid CAS Registry Number.
88122-95-6Relevant articles and documents
Total synthesis of SR 121463 A, a highly potent and selective vasopressin V2 receptor antagonist
Venkatesan,Davis,Altas,Snyder,Liotta
, p. 3653 - 3661 (2007/10/03)
SR 121463 A, 1, is a promising nonpeptide prototype for potent and selective antagonism of the vasopressin V2 receptor subtype and, thus, a candidate for control of the clinically debilitating condition of hyponatremia and its associated syndromes. In the present work, we present a novel and stereoselective synthesis that stems from the preparation of three key intermediates: the substituted benzenesulfonyl chloride 2, the N-protected oxindole 3, and protected dibromide 4. The synthesis of 1 has been achieved in good overall yield, each step proceeding in greater than 80% yield. In addition, intermediate 2 and the syn isomer of 1 were prepared with complete control of stereochemistry. The latter reduction appears to proceed by lithium cation mediated chelation control. Molecular mechanics calculations with the MM3* and MMFF force fields underscore geometric and energetic aspects of the reaction.
