88126-50-5

Basic information

• Product Name: 2H-1-Benzopyran-2-one, 4-(3,4-dimethoxyphenyl)-5,7-dimethoxy-
• CAS NO: 88126-50-5
• Molecular Formula: C19H18O6
• Molecular Weight: 342.348
• Mol File: 88126-50-5.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2H-1-Benzopyran-2-one, 4-(3,4-dimethoxyphenyl)-5,7-dimethoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-1-Benzopyran-2-one, 4-(3,4-dimethoxyphenyl)-5,7-dimethoxy-(88126-50-5)
• EPA Substance Registry System: 2H-1-Benzopyran-2-one, 4-(3,4-dimethoxyphenyl)-5,7-dimethoxy-(88126-50-5)

Safety Data

• Hazardous Substances Data: 88126-50-5(Hazardous Substances Data)

Upstream product

• 2555-38-6 4-hydroxy-5,7-dimethoxycoumarin 
• 62495-41-4 2-hydroxy-3',4,4',6-tetramethoxy benzophenone 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 186581-53-3 diazomethane 
• 88126-45-8 3'-hydroxy-4',5,7-trimethoxy-4-phenyl-2H-1-benzopyran-2-one 
• 88126-47-0 3',4'-dihydroxy-5,7-dimethoxy-4-phenylcoumarin 
• 122775-35-3 3,4-Dimethoxyphenylboronic acid 
• 185418-17-1 5,7-dimethoxy-4-trifluoromethylsulfonyloxychromen-2-one 

Relevant articles and documents

Cytotoxic constituents of the roots of Exostema acuminatum

Bioassay-guided phytochemical investigation of the roots of Exostema acuminatum (Rubiaceae) using human oral epidermoid carcinoma (KB) cells as a monitor, led to the isolation of two norditerpenoids, namely, (16R)-ent-16,17-dihydroxy-19-nor-kaur-4-en-3-one (1) and (16S)-ent-16,17-dihydroxy-19-nor-kaur-4-en-3-one (2), and six previously known 4-phenylcoumarins (3-8). The structure and relative stereochemistry of the novel compound 1 were determined by X-ray crystallography. All isolates were tested against a panel of human tumor cell lines, and the 4-phenylcoumarins showed significant cytotoxicity, with 3'-hydroxy-5,7,4'-trimethoxy-4-phenylcoumarin (5) and 8-hydroxy-5,7,4'-trimethoxy-4-phenylcoumarin (6) exhibiting the most potent activity. Two of the 4-phenylcoumarins, 5,7,4'-trimethoxy-4-phenylcoumarin (3) and 6, were evaluated in an in vivo P388 murine leukemia model. (C) 2000 Elsevier Science Ltd.

Synthesis of neoflavones by Suzuki arylation of 4-substituted coumarins

Palladium-catalysed coupling of the 4-chloro- or 4-bromo-coumarins 1-4 with arylboronic acids 5-13 under the Suzuki reaction conditions constitutes an efficient access to 4-arylcoumarins. These 4-arylcoumarins can also be obtained in good yields (70-97%)

SYNTHESIS OF 4-ARYLCOUMARINS FROM COUTAREA HEXANDRA

Key Word Index - Coutarea hexandra; Rubiaceae; neoflavonoids; 4-arylcoumarins; synthesis. - The structures assigned to the 5,7-dimethoxy-4-arylcoumarins isolated from Coutarea hexandra have been confirmed by synthesis, via Pechmann condensation of phlorog