88143-75-3

Basic information

• Product Name: methyl (L)-N^α-phthaloylseryl-(D)-phenylglycine
• Synonyms: methyl (L)-N^α-phthaloylseryl-(D)-phenylglycine
• CAS NO: 88143-75-3
• Molecular Weight: 382.373
• Mol File: 88143-75-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl (L)-N^α-phthaloylseryl-(D)-phenylglycine(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (L)-N^α-phthaloylseryl-(D)-phenylglycine(88143-75-3)
• EPA Substance Registry System: methyl (L)-N^α-phthaloylseryl-(D)-phenylglycine(88143-75-3)

Safety Data

• Hazardous Substances Data: 88143-75-3(Hazardous Substances Data)

Upstream product

• 875-74-1 (R)-phenylglycine 
• 29588-89-4 (2S)-2-(1,3-dioxoisoindolin-2-yl)-3-hydroxypropanoic acid 
• 19883-41-1 D-phenylglycine methyl ester hydrochloride 

Downstream Products

• 64027-40-3 [(S)-3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-oxo-azetidin-1-yl]-phenyl-acetic acid methyl ester 

Relevant articles and documents

The direct chemical conversion of peptides to β-lactams

Appropriately protected seryldipeptides which have a relatively acidic proton (H1 of 1) on the α' C can be efficiently converted to β-lactams by reaction with azodicarboxylates and triphenylphosphine. Application of the same reaction conditions to serylamides which lack an acidic α' proton provided dehydropeptides as the major product. Model reactions and potential intermediates which rationalize these results are described.