88145-90-8

Basic information

• Product Name: 2，4-dihydroxyl-6-fluoroquinazoline
• Synonyms: 6-fluoro-2,4(1H,3H)-Quinazolinedione;6-fluoro-1H-quinazoline-2,4-dione;6-Fluoro-1,2,3,4-tetrahydroquinazoline-2,4-dione;2，4-dihydroxyl-6-fluoroquinazoline;6-Fluoroquinazoline-2,4-diol;2,4-Dihydroxy-6-fluoroquinazoline;6-Fluoroquinazoline-2,4(1H,3H)-dione
• CAS NO: 88145-90-8
• Molecular Formula: C₈H₅FN₂O₂
• Molecular Weight: 180.137
• Mol File: 88145-90-8.mol
• Article Data: 1

Chemical Properties

• Melting Point: >300 °C
• Appearance: /
• Density: 1.434g/cm³
• Refractive Index: 1.562
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 10.09±0.20(Predicted)
• CAS DataBase Reference: 2，4-dihydroxyl-6-fluoroquinazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2，4-dihydroxyl-6-fluoroquinazoline(88145-90-8)
• EPA Substance Registry System: 2，4-dihydroxyl-6-fluoroquinazoline(88145-90-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 88145-90-8(Hazardous Substances Data)

Usage

General Description

2,4-dihydroxyl-6-fluoroquinazoline is a chemical compound that belongs to the quinazoline family. It is characterized by the presence of two hydroxyl groups and a fluorine atom on the quinazoline ring. 2，4-dihydroxyl-6-fluoroquinazoline has potential applications in medicinal chemistry, particularly in the development of pharmaceuticals and biologically active molecules. It may exhibit certain pharmacological activities due to its structural features, and further research into its properties and potential uses is warranted. Additionally, 2,4-dihydroxyl-6-fluoroquinazoline may serve as a valuable building block for the synthesis of more complex organic compounds and functional materials.

InChI:InChI=1/C8H5FN2O2/c9-4-1-2-6-5(3-4)7(12)11-8(13)10-6/h1-3H,(H2,10,11,12,13)

Upstream product

• 319-24-4 2-amino-5-fluoro-benzoic acid methyl ester 
• 57-13-6 urea 

Downstream Products

• 134517-57-0 2,4-dichloro-6-fluoro-quinazoline 
• 769158-12-5 2-chloro-6-fluoroquinazolin-4(3H)-one 
• 769158-13-6 2-((2-chloro-6-fluoro-4-oxoquinazolin-3(4H)-yl)methyl)benzonitrile 
• 1292802-51-7 C₂₀H₁₇FN₄O₂ 
• 1292802-52-8 C₂₉H₃₅FN₆O 
• 1292802-53-9 C₂₈H₃₃FN₆O 
• 1292802-54-0 C₂₇H₂₉Cl₂FN₆O 
• 113082-27-2 2-chloro-6-fluoroquinazoline 

Relevant articles and documents

Synthesis and biological evaluation of 2,4-diaminoquinazoline derivatives as novel heat shock protein 90 inhibitors

Novel 2,4-diaminoquinazoline derivatives originating from a virtual screening approach were designed, synthesized and their biological activities as heat shock protein 90 (Hsp90) inhibitors were evaluated. The prepared compounds exhibited significant anti-proliferative activities against DU-145, HT-29, HCT-116, A375P and MCF-7 cancer cell lines. The selected compounds were tested against Her2, a client protein of Hsp90, and showed significant reduction in Her2 protein expression. Compound 6b was found the most potent, reduced Her2 protein expression levels and induced Hsp70 protein expression levels significantly.