881677-39-0

Basic information

• Product Name: 4-chloromethyl-N-[4-methyl-3-(4-pyridin-2-yl-pyrimidin-2-ylamino)-phenyl]-benzamide
• Synonyms: 4-chloromethyl-N-[4-methyl-3-(4-pyridin-2-yl-pyrimidin-2-ylamino)-phenyl]-benzamide
• CAS NO: 881677-39-0
• Molecular Weight: 429.909
• Mol File: 881677-39-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-chloromethyl-N-[4-methyl-3-(4-pyridin-2-yl-pyrimidin-2-ylamino)-phenyl]-benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloromethyl-N-[4-methyl-3-(4-pyridin-2-yl-pyrimidin-2-ylamino)-phenyl]-benzamide(881677-39-0)
• EPA Substance Registry System: 4-chloromethyl-N-[4-methyl-3-(4-pyridin-2-yl-pyrimidin-2-ylamino)-phenyl]-benzamide(881677-39-0)

Safety Data

• Hazardous Substances Data: 881677-39-0(Hazardous Substances Data)

Upstream product

• 3006-96-0 3-hydroxymethyl-benzoic acid 
• 1122-62-9 2-acetylpyridine 
• 66521-54-8 3-(dimethylamino)-1-(pyridine-2-yl)prop-2-en-1-one 
• 7745-93-9 2-bromo-4-nitrotoluene 
• 66521-65-1 4-(pyridin-2-yl)pyrimidine-2-ylamine 
• 475587-23-6 N-(2-methyl-5-nitrophenyl)-4-(pyridin-2-yl)pyrimidin-2-amine 
• 99-99-0 1-methyl-4-nitrobenzene 
• 475587-24-7 N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyridinamine 
• 876-08-4 p-(chloromethyl)benzoyl chloride 

Downstream Products

• 872672-74-7 N-(4-methyl-3-(4-(pyridin-2-yl)pyrimidin-2-ylamino)phenyl)-4-((4-methylpiperazin-1-yl)methyl) benzamide 

Relevant articles and documents

A facile total synthesis of imatinib base and its analogues

Imatinib and its analogues were successfully synthesized by an improved method in 19.5-46.2% total yield of six main steps. Pyrimidinyl amine was prepared by the reaction of enaminone and guanidine nitrate without the use of a toxic cyanamide. N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl) pyrimidin-2-amine as a key intermediate for the synthesis of imatinib was prepared by coppercatalyzed iV-arylation of heteroarylamme in 82% yield. The copper salts were used instead of the expensive palladium compounds in this C-N bond-forming reaction. The intermediate nitro compound was reduced by a N2H 4.H2O/FeCl3/C system using water as a solvent in good yield.