881681-01-2 Usage
Description
Vonoprazan FuMarate, also known as TAK-438, is a novel oral anti-gastric acid drug developed collaboratively by Takeda Pharmaceutical and Otsuka Pharmaceutical. It is characterized by its ability to inhibit gastric acid secretion, making it a promising candidate for the treatment of various gastrointestinal conditions.
Used in Pharmaceutical Industry:
Vonoprazan FuMarate is used as a therapeutic agent for the treatment of erosive esophagitis, gastric ulcer, and duodenal ulcer. Its application is based on its ability to reduce gastric acid secretion, thereby promoting healing and alleviating symptoms associated with these conditions.
benefits
Compared with traditional irreversible proton pump inhibitors (such as omeprazole, esomeprazole, etc.), Vonoprazan fumarate advantages:① The onset of action is good, and the maximum acid-suppressing effect will be achieved on the first day of administration;② Oral administration, not affected by gastric acid damage;③It can improve the phenomenon of acid breakthrough at night.
Mechanism of action
Vonoprazan fumarate is a potassium ion (K+) competitive acid blocker (P-CAB), which is a reversible proton pump inhibitor. It can inhibit the combination of K+ and H+-K+-ATPase (proton pump), so that secretion of gastric acid is terminated. Vonoprazan fumarate has a strong and lasting inhibitory effect on gastric acid secretion.
Check Digit Verification of cas no
The CAS Registry Mumber 881681-01-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,1,6,8 and 1 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 881681-01:
(8*8)+(7*8)+(6*1)+(5*6)+(4*8)+(3*1)+(2*0)+(1*1)=192
192 % 10 = 2
So 881681-01-2 is a valid CAS Registry Number.
881681-01-2Relevant articles and documents
Preparation method of funolasan fumarate
-
, (2022/01/10)
The present invention provides a method for preparing funorasine fumarate, comprising the following steps: (1) the compound of formula I is azidine to give a compound of formula II.; (2) the compound of formula II. is cyclized with the compound of formula III. to give a compound of formula IV.; (3) the compound of formula IV. is condensed with a compound of formula VI. to give a compound of formula VII. compound; (4) a compound of formula VII. is deprotected with acid to obtain a vonorasin free base; (5) a vonorasin free base is salted with fumarate to give vonorasin fumarate. According to the method of the present invention to synthesize vonoracin fumarate, compared with the prior art, the total yield of vonora fumarate increased to more than 60%, and the yield has been greatly improved. Furthermore, compound formula IV. can be used as a new intermediate for the preparation of funolasine fumarate.
Preparation method of high-purity vonoprazan fumarate
-
Paragraph 0054, (2021/05/26)
The invention discloses a preparation method of high-purity vonoprazan fumarate. The preparation method comprises the steps of 1, preparing 5-(2-fluorophenyl)-1-(pyridine-3-sulfonyl) pyrrole-3-formaldehyde; 2, dissolving the 5-(2-fluorophenyl)-1-(pyridine
Vonoprazan fumarate intermediate and preparation method thereof
-
Paragraph 0039; 0084; 0086-0087; 0089-0090; 0092, (2021/10/27)
The invention provides a vonoprazan fumarate intermediate compound as well as a preparation method and application thereof. Compared with the prior art, the technical scheme provided by the invention avoids the hydrogenation reaction operation with higher
