881831-38-5

Basic information

• Product Name: (2S,4R)-1-(2-Nitro-benzenesulfonyl)-2-((S)-2-oxo-pyrrolidin-3-yloxy)-1,2,3,4-tetrahydro-pyridine-4-carboxylic acid ethyl ester
• Synonyms: (2S,4R)-1-(2-Nitro-benzenesulfonyl)-2-((S)-2-oxo-pyrrolidin-3-yloxy)-1,2,3,4-tetrahydro-pyridine-4-carboxylic acid ethyl ester
• CAS NO: 881831-38-5
• Molecular Weight: 439.446
• Mol File: 881831-38-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,4R)-1-(2-Nitro-benzenesulfonyl)-2-((S)-2-oxo-pyrrolidin-3-yloxy)-1,2,3,4-tetrahydro-pyridine-4-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4R)-1-(2-Nitro-benzenesulfonyl)-2-((S)-2-oxo-pyrrolidin-3-yloxy)-1,2,3,4-tetrahydro-pyridine-4-carboxylic acid ethyl ester(881831-38-5)
• EPA Substance Registry System: (2S,4R)-1-(2-Nitro-benzenesulfonyl)-2-((S)-2-oxo-pyrrolidin-3-yloxy)-1,2,3,4-tetrahydro-pyridine-4-carboxylic acid ethyl ester(881831-38-5)

Safety Data

• Hazardous Substances Data: 881831-38-5(Hazardous Substances Data)

Upstream product

• 5455-59-4 2-Nitrobenzenesulfonamide 
• 2960-66-9 4-oxo-but-2-enoic acid ethyl ester 
• 881830-67-7 (S)-3-(vinyloxy)-2-pyrrolidinone 
• 881830-63-3 ethyl (E)-4-[(2-nitrophenylsulfonyl)imino]-2-butenoate 

Downstream Products

• 881831-55-6 (2S,4S)-1-(2-Amino-benzenesulfonyl)-2-((S)-2-oxo-pyrrolidin-3-yloxy)-piperidine-4-carboxylic acid ethyl ester 

Relevant articles and documents

Diastereoselective Diels-Alder reactions of N-sulfonyl-1-aza-1,3-butadienes with optically active enol ethers: An asymmetric variant of the 1-azadiene Diels-Alder reaction

The first detailed study of a room-temperature asymmetric Diels-Alder reaction of N-sulfonyl-1-aza-1,3-butadienes is reported enlisting a series of 19 enol ethers bearing chiral auxiliaries, with many providing highly diastereoselective (endo and facial diastereoselection) reactions, largely the result of an exquisitely organized [4+2] cycloaddition transition state. Three new, readily accessible, and previously unexplored auxiliaries rationally emerged from the studies and provide remarkable selectivities (two of these give 49:1 endo:exo and 48:1 facial selectivity) that promise to be useful in systems beyond those detailed.