88222-72-4Relevant articles and documents
Insights into the Biosynthesis of Cyclic Guanidine Alkaloids from Crambeidae Marine Sponges
Silva, Siguara B. L.,Oberh?nsli, Fran?ois,Tribalat, Marie-Aude,Genta-Jouve, Grégory,Teyssié, Jean-Louis,Dechraoui-Bottein, Marie-Yasmine,Gallard, Jean-Fran?ois,Evanno, Laurent,Poupon, Erwan,Thomas, Olivier P.
, p. 520 - 525 (2018/12/13)
Among the outstanding chemical diversity found in marine sponges, cyclic guanidine alkaloids, present in species of the family Crambeidae, are particularly attractive, not only because of their unique chemical features, but also due to a broad range of bi
Small molecule inhibitors of bacterial quorum sensing and biofilm formation
Geske, Grant D.,Wezeman, Rachel J.,Siegel, Adam P.,Blackwell, Helen E.
, p. 12762 - 12763 (2007/10/03)
Bacteria monitor their local population densities using small molecules (or autoinducers) in a process known as quorum sensing. Here, we report a new and efficient synthetic route to naturally occurring bacterial autoinducers [N-acyl L-homoserine lactones (AHLs)] that is readily amenable to the synthesis of analogues. This route has been applied in the first synthesis of a library of non-native AHLs. Evaluation of these compounds in bacterial reporter gene and biofilm assays has revealed a potent set of quorum sensing antagonists. These ligands will serve as valuable new tools to explore the role of quorum sensing in bacterial pathogenesis. Copyright
New potential immunoenhancing compounds. Synthesis and pharmacological evaluation of new long-chain 2-amido-2-deoxy-D-glucose derivatives
Valcavi,Albertoni,Brandt,Corsi,Farina,Foresta,Pascucci,Ramacci
, p. 1190 - 1195 (2007/10/02)
A series of long-chain fatty acids and the corresponding 2-hydroxy, 2-oxo, 3-hydroxy acid glucosamides were evaluated as immunomodulating compounds. In a preliminary screening, 2-[(2-ethoxycarbonyloxy)tetradecanoyl-amino]-2-deoxy-D-glucose (2b) and 2-(3-hydroxydodecanoyl-amino)-2-deoxy-D-glucose (5a) resulted to be the most effective in enhancing the glucosamine activity. The findings of in vitro-ex vivo tests (unidirectional mixed lymphocyte culture reaction and primary antibody production) and in vivo tests (delayed type hypersensitivity, protection against bacterial or fungal infection and against Sarcoma 180 or Lewis lung carcinoma transplants) were very encouraging and allowed to assume for the two substances a protective activity, presumably through the ability of activating phagocytic and NK cells.
