88254-07-3 Usage
Description
5,12-Naphthacenedione, 10-3-(3-cyano-4-morpholinyl)-2,3,6-trideoxy-α-L-lyxo-hexopyranosyloxy-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, commonly known as Daunorubicin, is a chemotherapy medication used to treat certain types of cancer, including leukemia and lymphoma. It belongs to a class of drugs known as anthracyclines and works by interfering with the growth and spread of cancer cells in the body. Daunorubicin is considered an essential medicine by the World Health Organization and is included on the WHO Model List of Essential Medicines.
Uses
Used in Oncology:
Daunorubicin is used as an anticancer agent for the treatment of leukemia and lymphoma. It is particularly effective in treating acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). The anthracycline compound works by inhibiting the synthesis of DNA and RNA, thereby preventing the replication and spread of cancer cells.
Used in Drug Formulations:
Daunorubicin is used in various drug formulations, often in combination with other chemotherapy agents, to enhance the effectiveness of cancer treatment. These formulations are designed to target specific types of cancer and may be administered intravenously by healthcare professionals.
Used in Research:
As a member of the anthracycline class of drugs, Daunorubicin is also used in research settings to study the mechanisms of action and resistance in cancer cells. This research helps in the development of new and more effective cancer treatments and drug delivery systems.
Check Digit Verification of cas no
The CAS Registry Mumber 88254-07-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,8,2,5 and 4 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 88254-07:
(7*8)+(6*8)+(5*2)+(4*5)+(3*4)+(2*0)+(1*7)=153
153 % 10 = 3
So 88254-07-3 is a valid CAS Registry Number.
88254-07-3Relevant articles and documents
Intensely potent morpholinyl anthracyclines
Acton,Tong,Mosher,Wolgemuth
, p. 638 - 645 (2007/10/02)
3'-Deamino-3'-(3-cyano-4-morpholinyl)doxorubicin is a new analogue that is 100 to 1000 times more potent than doxorubicin against tumors in cell culture or in mice, that is active by intraperitoneal, intravenous, or oral dosing, and that does not produce chronic myocardial lesions in mice. This analogue was encountered in studies on the reductive alkylation of doxorubicin and daunorubicin with 2,2'-oxybis[acetaldehyde], which constructs a morpholino ring incorporating the amino N. The morpholinyl nitrile byproducts are separated by virtue of their nonbasicity from the expected morpholino derivatives. The 13-dihydro and 5-imino derivatives are also described in this important new class of anthracyclines.