88255-19-0

Basic information

• Product Name: 5-Heptynoic acid, 7-phenyl-, methyl ester
• CAS NO: 88255-19-0
• Molecular Formula: C14H16O2
• Molecular Weight: 216.28
• Mol File: 88255-19-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-Heptynoic acid, 7-phenyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Heptynoic acid, 7-phenyl-, methyl ester(88255-19-0)
• EPA Substance Registry System: 5-Heptynoic acid, 7-phenyl-, methyl ester(88255-19-0)

Safety Data

• Hazardous Substances Data: 88255-19-0(Hazardous Substances Data)

Upstream product

• 53293-00-8 hex-5-ynoic acid 
• 100-44-7 benzyl chloride 
• 75-05-8 acetonitrile 
• 102921-09-5 2-benzyl-3-<<(4-methylphenyl)sulfonyl>azo>cyclohex-2-en-1-one 
• 102921-10-8 7-phenyl-1,1,1-trimethoxy-5-heptyne 

Downstream Products

• 88255-07-6 7-phenyl-5-heptynoic acid 

Relevant articles and documents

Palladium-catalyzed Heck alkynylation of benzyl chlorides

An efficient and general protocol for the palladium-catalyzed Heck alkynylation of benzyl chlorides was developed. A catalyst system comprised of PdCl2(CH3CN)2 and 2-dicyclohexylphosphino- 2′,4′,6′-triisopropylbiphenyl (XPhos), with Cs 2CO3 as the base, efficiently couples a wide range of functionalized terminal alkynes and substituted benzyl chlorides at 65 °C. We have also demonstrated that the corresponding aryl allene product can be selected for using an excess amount of base and higher reaction temperatures (80 °C) in a one-pot procedure. Georg Thieme Verlag Stuttgart.

7-Aryl-hept-5-ynoic acids and derivatives thereof

7-arylhept-5-ynoic acids and derivatives thereof are anti-allergy and anti-inflammatory agents. As such, they are useful in the treatment of allergy-caused diseases, particularly chronic obstructive lung diseases.