882856-58-8

Basic information

• Product Name: tert-butyl(3R,4R)-4-(2,4,5-trifluorophenyl)piperidin-3-ylcarbamate
• Synonyms: tert-butyl(3R,4R)-4-(2,4,5-trifluorophenyl)piperidin-3-ylcarbamate
• CAS NO: 882856-58-8
• Molecular Weight: 330.35
• Mol File: 882856-58-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: tert-butyl(3R,4R)-4-(2,4,5-trifluorophenyl)piperidin-3-ylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl(3R,4R)-4-(2,4,5-trifluorophenyl)piperidin-3-ylcarbamate(882856-58-8)
• EPA Substance Registry System: tert-butyl(3R,4R)-4-(2,4,5-trifluorophenyl)piperidin-3-ylcarbamate(882856-58-8)

Safety Data

• Hazardous Substances Data: 882856-58-8(Hazardous Substances Data)

Upstream product

• 165047-24-5 2,4,5-trifluorobenzaldehyde 
• 882856-64-6 dimethyl 2-cyano-3-(2,4,5-trifluorophenyl)pentanedioate 
• 888321-36-6 ethyl 3-(2,4,5-trifluorophenyl)acrylate 
• 882856-76-0 tert-butyl (3R,4R)-1-benzyl-4-(2,4,5-trifluorophenyl)piperidin-3-ylcarbamate 

Downstream Products

• 936482-39-2 tert-butyl (3R,4R)-1-(6-chloropyrimidin-4-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-ylcarbamate 
• 936482-41-6 tert-butyl(3R,4R)-1-(4-chloro-1,3,5-triazin-2-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-ylcarbamate 
• 882856-88-4 tert-butyl [(3R,4R)-1-[(6-methylamino)-5-nitropyridin-2-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-yl]carbamate 
• 882856-82-8 tert-butyl [(3R,4R)-1-[6-(aminocarbonyl)-5-nitropyridin-2-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-yl]carbamate 

Relevant articles and documents

Discovery and structure - Activity relationships of piperidinone- and piperidine-constrained phenethylamines as novel, potent, and selective dipeptidyl peptidase IV inhibitors

Dipeptidyl peptidase IV (DPP4) inhibitors are emerging as a new class of therapeutic agents for the treatment of type 2 diabetes. They exert their beneficial effects by increasing the levels of active glucagon-like peptide-1 and glucose-dependent insulino

AMINOPIPERIDINES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES

The present invention is directed to novel substituted aminopiperidines which are inhibitors of the dipeptidyl peptidase-IV enzyme ("DPP-IV inhibitors") and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.