88302-06-1

Basic information

• Product Name: RARECHEM AL BO 1862
• Synonyms: RARECHEM AL BO 1862;3-PYRIDINECARBOXYLIC ACID, 5-ACETYL-1,2-DIHYDRO-6-METHYL-2-OXO-;5-ACETYL-1,2-DIHYDRO-6-METHYL-2-OXO-3-PYRIDINECARBOXYLIC ACID;5-ACETYL-6-METHYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLIC ACID;AKOS VGYB0001124;5-acetyl-6-methyl-2-oxo-1,2-dihydro-3-pyridinecarboxylic acid(SALTDATA: FREE);5-Acetyl-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid;5-acetyl-2-keto-6-methyl-1H-pyridine-3-carboxylic acid
• CAS NO: 88302-06-1
• Molecular Formula: C9H9NO4
• Molecular Weight: 195.17
• Mol File: 88302-06-1.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 415.352°C at 760 mmHg
• Flash Point: 204.998°C
• Appearance: /
• Density: 1.364g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.553
• CAS DataBase Reference: RARECHEM AL BO 1862(CAS DataBase Reference)
• NIST Chemistry Reference: RARECHEM AL BO 1862(88302-06-1)
• EPA Substance Registry System: RARECHEM AL BO 1862(88302-06-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 88302-06-1(Hazardous Substances Data)

Usage

General Description

RARECHEM AL BO 1862 is a chemical substance with the chemical formula AlBO2. It is a rare earth borate compound, with a molecular weight of 118.535 g/mol. This chemical is used in various industrial applications, including as a catalyst in chemical reactions and as a component in the production of advanced materials. RARECHEM AL BO 1862 is known for its high purity and stability, making it a valuable and sought-after compound in the field of materials science and chemical engineering.

InChI:InChI=1/C9H9NO4/c1-4-6(5(2)11)3-7(9(13)14)8(12)10-4/h3H,1-2H3,(H,10,12)(H,13,14)

Upstream product

• 52600-53-0 5-acetyl-1,2-dihydro-6-methyl-2-oxonicotinonitrile 
• 52600-60-9 5-acetyl-1,2-dihydro-6-methyl-2-oxo-3-pyridine-carboxamide 
• 71407-96-0 methyl 5-acetyl-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate 
• 18856-72-9 3-dimethylaminomethylenepentane-2,4-dione 
• 33884-41-2 ethoxylideneacetylacetone 

Downstream Products

• 136117-46-9 5-acetyl-3-bromo-6-methyl-2(1H)-pyridinone 
• 58405-00-8 5-acetyl-3-chloro-6-methyl-2(1H)-pyridinone 
• 5220-65-5 5-acetyl-6-methyl-2(1H)-pyridinone 

Relevant articles and documents

Synthesis and pharmacological characterization of functionalized 2-pyridones structurally related to the cardiotonic agent milrinone

A new class of cardiotonic agents characterized by a 2-pyridone structure was synthesized. Appropriate sym-2-dimethylaminomethylene-1,3-diones reacted with methylcyanoacetate to afford the desired compounds. These derivatives were evaluated for their ability in inducing cardiotonic response on guinea pig isolated myocardial preparations. Compound 8b increased atrial contractility to an extent which is significantly higher than that of milrinone, the parent drug used as a reference compound. The pharmacological characterization and the docking studies performed on 8b highlighted its selective mechanism of action via type 3 PDE (PDE3) inhibition.

Novel alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones

This invention relates to alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones and to their use as cardiotonic agents useful in treating cardiac failure, and to the process useful in the preparation thereof.

Reaction of 2-Dimethylaminomethylene-1,3-diones with Dinucleophiles.V. Synthesis of 5-Acyl-1,2-dihydro-2-oxo-3-pyridinecarbonitriles and 1,2,5,6,7,8-Hexahydro-2,5-dioxo-3-quinolinecarboxamides

The reaction of open-chain sym-2-dimethylaminomethylene-1,3-diones Ia-d with sodium cyanoacetamide gave, generally in good yields, 6-substituted 5-acyl-1,2-dihydro-2-oxo-3-pyridinecarbonitriles IIa-d, whereas cyclohexane sym-2-dimethylaminomethylene-1,3-diones Ie-h afforded in general a mixture of 1,2,5,6,7,8-hexahydro-2,5-dioxo-3-quinolinecarbonitriles and 5,6,7,8-tetrahydro-2,5-dioxo-2H-1-benzopyran-3-carboxamides, the latter being isolated in two cases.The reaction of Ie-h with cyanoacetamide in refluxing anhydrous ethanol gave 1,2,5,6,7,8-hexahydro-2,5-dioxo-3-quinolinecarboxamides IIIe-h in excellent yields, whereas Ia-d did not react with the exception of Ia which afforded in good yield 3-pyridinecarboxamide IIIa.Other 3-pyridinecarboxamides were obtained by partial hydrolysis of nitriles IIb,d. 3-Pyridine and 3-quinoline carboxamides were hydrolyzed in satisfactory yields with hydrochloric acid to the corresponding carboxylic acids, which were decarboxylated in good yields to 5-acyl-2(1H)-pyridinones and 7,8-dihydro-2,5-(1H,6H)-quinolinediones, respectively, by reflux in quinoline containing a catalytic amount of copper powder.