88368-71-2

Basic information

• Product Name: 3-(3,4-dimethoxyphenyl)propionic acid hydrazide
• Synonyms: 3-(3,4-dimethoxyphenyl)propionic acid hydrazide
• CAS NO: 88368-71-2
• Molecular Weight: 224.26
• Mol File: 88368-71-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 3-(3,4-dimethoxyphenyl)propionic acid hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3,4-dimethoxyphenyl)propionic acid hydrazide(88368-71-2)
• EPA Substance Registry System: 3-(3,4-dimethoxyphenyl)propionic acid hydrazide(88368-71-2)

Safety Data

• Hazardous Substances Data: 88368-71-2(Hazardous Substances Data)

Upstream product

• 27798-73-8 methyl 3-(3,4-dimethoxyphenyl)propionate 
• 20583-78-2 ethyl (E)-3,4-dimethoxycinnamate 
• 2107-70-2 3,4-methoxycinnamic acid 
• 5462-13-5 ethyl 3-(3,4-dimethoxyphenyl)propionate 

Downstream Products

• 446853-44-7 N-(3,4-dimethoxy-phenethyl)-N'-p-tolyl-urea 
• 700855-80-7 N-(3,4-dimethoxy-phenethyl)-N'-m-tolyl-urea 
• 67616-08-4 N'-phenyl-N-<2-(3,4-dimethoxyphenyl)ethyl>urea 
• 859195-16-7 (6,7-dimethoxy-3,4-dihydro-[1]isoquinolyl)-methyl-phenyl-amine 
• 39052-28-3 (6,7-dimethoxy-3,4-dihydro-2H-[1]isochinolyLiDene)-m-tolyl-amine 
• 39052-30-7 (6,7-dimethoxy-3,4-dihydro-2H-[1]isochinolyLiDene)-p-tolyl-amine 
• 39052-32-9 6,7-Dimethoxy-1-[(E)-phenylimino]-1,2,3,4-tetrahydroisochinolin 
• 35167-81-8 3,4-dimethoxyphenethyl isocyanate 
• 5467-91-4 1,3-bis[2-(3,4-dimethoxyphenyl)ethyl]urea 
• 156141-41-2 methyl 2-[3-(3,4-dimethoxyphenyl)propanoyl]hydrazinecarboxylate 
• 21997-97-7 3-(3,4-dimethoxy-phenyl)-propionyl azide 

Relevant articles and documents

Exploration of diphenylalkyloxadiazoles as novel cardiac myosin activator

To explore novel cardiac myosin activator, a series of diphenylalkyl substituted 1,3,4-oxadiazoles and 1,2,4-oxadiazoles have been prepared and tested for cardiac myosin ATPase activation in vitro. In all cases, three carbon spacer between the oxadiazole core and one of the phenyl ring was considered crucial. In case of 1,3,4-oxadiazole, zero to two carbon spacer between oxadiazole core and other phenyl ring are favorable. Phenyl ring can be replaced by cyclohexyl moiety. In case of 1,2,4-oxadiazole, zero or one carbon spacer between the oxadiazole and other phenyl ring are favorable. Introduction of hydrogen bonding donor (NH) group at the 2nd position of the 1,3,4-oxadiazole enhances the activity. Substitutions on either of the phenyl rings or change of phenyl ring to other heterocycle are not tolerated for both the oxadiazoles. The prepared oxadiazoles showed selective activation for cardiac muscle over smooth and skeleton muscles.

Design and synthesis of 1,2-dithiolane derivatives and evaluation of their neuroprotective activity

We designed and synthesized new analogues containing 1,2-dithiolane-3-alkyl and protected or free catechol moieties connected through heteroaromatic rings such as triazole, 1,2,4-oxadiazole, 1,3,4-oxadiazole, tetrazole or thiazole in order to explore the influence of the bioisosteric replacement of the amide group on the neuroprotective activity of the lipoic acid/dopamine conjugate. Evaluation of the activity of the new compounds, using glutamate-challenged hippocampal HT22 cells, showed that incorporation of heteroaromatic rings in the alkyl-1,2-dithiolane moieties in conjunction with another antioxidant, in this case catechol, may result in strong neuroprotective activity.

Syntheses and anti-inflammatory and analgesic activities of hydroxamic acids and acid hydrazides

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