88371-31-7

Basic information

• Product Name: Benzoic acid, 3-[(3-ethoxy-1-oxo-2-propenyl)amino]-, methyl ester
• CAS NO: 88371-31-7
• Molecular Formula: C13H15NO4
• Molecular Weight: 249.266
• Mol File: 88371-31-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 3-[(3-ethoxy-1-oxo-2-propenyl)amino]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 3-[(3-ethoxy-1-oxo-2-propenyl)amino]-, methyl ester(88371-31-7)
• EPA Substance Registry System: Benzoic acid, 3-[(3-ethoxy-1-oxo-2-propenyl)amino]-, methyl ester(88371-31-7)

Safety Data

• Hazardous Substances Data: 88371-31-7(Hazardous Substances Data)

Upstream product

• 4518-10-9 Methyl 3-aminobenzoate 
• 6191-99-7 3-ethoxyacryloyl chloride 
• 99-05-8 meta-aminobenzoic acid 
• 6191-99-7 (2E)-3-ethoxyprop-2-enoyl chloride 

Downstream Products

• 70758-34-8 methyl 2-oxo-1,2-dihydroquinoline-5-carboxylate 
• 70758-34-8 2-oxy-quinoline-5-carboxylic acid methyl ester 

Relevant articles and documents

ANTI-ANGIOGENESIS COMPOUND, INTERMEDIATE AND USE THEREOF

Disclosed are an anti-abnormal proliferation of angiogenesis compound represented by formula I, use and intermediate thereof. The compound has good effect against abnormal proliferation of angiogenesis, and the activity of the compound is produced by inhibiting VEGFR2. The compound can be used for treating diseases, such as wet macular degeneration, inflammation, malignant tumor and the like, caused by abnormity of angiogenesis and protein kinases such as VEGFR2, FGFR2 and the like.

Synthesis and molecular modeling study of new trimeric quinoline derivatives

Di- and trimeric quinoline derivatives have been recently described as potential modulators of Bcl-2 family protein interactions. However, only a few trimeric compounds have been described so far and an enlargement of the number of analogs of this class is needed to expand the structure-activity relationship study. Therefore, the synthesis of six new trimeric quinoline derivatives is reported. Moreover molecular modeling experiments were performed to study the conformational arrangement of compound 36 in Bak binding site of Bcl-x L, showing that these compounds could be potential ligands for Bcl-xL.