88372-33-2

Basic information

• Product Name: 1-phenyl-2-(piperazin-1-yl)ethanone
• Synonyms: 1-phenyl-2-(piperazin-1-yl)ethanone;1-(Phenylacetyl)piperazine, [2-Oxo-2-(piperazin-1-yl)ethyl]benzene;2-Phenyl-1-(1-piperazinyl)ethanone;2-phenyl-1-(piperazin-1-yl)ethanone;Ethanone, 2-phenyl-1-(1-piperazinyl)-
• CAS NO: 88372-33-2
• Molecular Formula: C₁₂H₁₆N₂O
• Molecular Weight: 204
• Mol File: 88372-33-2.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 385℃
• Flash Point: 186℃
• Appearance: /
• Density: 1.101
• Vapor Pressure: 4.04E-06mmHg at 25°C
• Refractive Index: 1.549
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 1-phenyl-2-(piperazin-1-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenyl-2-(piperazin-1-yl)ethanone(88372-33-2)
• EPA Substance Registry System: 1-phenyl-2-(piperazin-1-yl)ethanone(88372-33-2)

Safety Data

• Hazardous Substances Data: 88372-33-2(Hazardous Substances Data)

Usage

General Description

1-phenyl-2-(piperazin-1-yl)ethanone, also known as 1-phenyl-2-(1-piperazinyl)ethan-1-one, is a chemical compound that belongs to the class of arylketones. It has a molecular formula of C13H16N2O and a molecular weight of 216.28 g/mol. 1-phenyl-2-(piperazin-1-yl)ethanone is commonly used in the pharmaceutical industry as a precursor for the synthesis of various drugs and active pharmaceutical ingredients. It has also been studied for its potential in treating conditions such as anxiety, depression, and schizophrenia. Additionally, 1-phenyl-2-(piperazin-1-yl)ethanone has been identified as a dopamine receptor antagonist, which may make it useful in the development of new antipsychotic medications. However, further research is needed to explore its full therapeutic potential and any potential side effects.

InChI:InChI=1/C12H16N2O/c15-12(14-8-6-13-7-9-14)10-11-4-2-1-3-5-11/h1-5,13H,6-10H2

Upstream product

• 110-85-0 piperazine 
• 103-82-2 phenylacetic acid 
• 7436-90-0 2,2-dibromostyrene 
• 142-64-3 piperazine dihydrochloride 
• 55628-82-5 1-(Phenylacetyl)imidazole 
• 23776-85-4 N-(phenylacetyl)oxysuccinimide 
• 103-80-0 phenylacetyl chloride 
• 999-97-3 1,1,1,3,3,3-hexamethyl-disilazane 
• 253175-91-6 tert-butyl 4-(2-phenylacetyl)piperazine-1-carboxylate 

Downstream Products

• 239100-92-6 1-phenylacetyl-4-[2-(tert-butoxycarbonylamino)acetyl]piperazine 
• 239100-94-8 1-phenylacetyl-4-[4-(tert-butoxycarbonylamino)butyryl]piperazine 
• 239100-93-7 1-phenylacetyl-4-[3-(tert-butoxycarbonylamino)propionyl]piperazine 
• 239100-95-9 1-phenylacetyl-4-[6-(tert-butoxycarbonylamino)hexanoyl]piperazine 
• 1054665-48-3 4-Phenylacetyl-piperazine-1-carboxylic acid (S)-((2R,3R,4S)-3-acetylamino-4-azido-6-methoxycarbonyl-3,4-dihydro-2H-pyran-2-yl)-((R)-2-oxo-[1,3]dioxolan-4-yl)-methyl ester 
• 1099094-40-2 9-(4-{4-[phenyl-acetyl]-piperazino}-butyl)-9H-fluorene-9-carboxylic acid-N-methyl-N-ethyl-amide 
• 461415-11-2 2-(4-chlorophenoxy)-1-(4-(2-phenylacetyl)piperazin-1-yl)ethanone 
• 1599431-86-3 2-(4-bromophenoxy)-1-(4-(2-phenylacetyl)piperazin-1-yl)ethanone 
• 1018574-27-0 2-chloro-1-(4-(2-phenylacetyl)piperazin-1-yl)ethanone 
• 1599431-88-5 (E)-1-(4-(2-phenylacetyl)piperazin-1-yl)-3-(p-tolyl)prop-2-en-1-one 
• 1599431-89-6 (E)-3-(4-methoxyphenyl)-1-(4-(2-phenylacetyl)piperazin-1-yl)prop-2-en-1-one 
• 1599431-90-9 (E)-3-(3,4-dichlorophenyl)-1-(4-(2-phenylacetyl)piperazin-1-yl)prop-2-en-1-one 
• 1599431-91-0 (E)-3-(3-fluoro-4-methylphenyl)-1-(4-(2-phenylacetyl)piperazin-1-yl)prop-2-en-1-one 
• 1599431-87-4 (E)-3-(4-bromophenyl)-1-(4-(2-phenylacetyl)piperazin-1-yl)prop-2-en-1-one 

Relevant articles and documents

Application of ethyl benzamide compound to preparation of local anesthetics

The invention provides an application of an ethyl benzamide compound to preparation of local anesthetics. The structure of the compound is shown in the following formula, and the compound has the characteristics of small toxic and side effects, short time

Oxazolo[4,5-b]pyridine-Based Piperazinamides as GSK-3β Inhibitors with Potential for Attenuating Inflammation and Suppression of Pro-Inflammatory Mediators

Recent studies reveal that glycogen synthase kinase-3β (GSK-3β) acts as a pro-inflammatory enzyme, and by inhibiting this kinase, inflammation can be controlled. In this regard, a series of 17 piperazine-linked oxazolo[4,5-b]pyridine-based derivatives was

Synthesis and biological evaluation of substituted 4-(thiophen-2-ylmethyl)- 2H-phthalazin-1-ones as potent PARP-1 inhibitors

We have developed a series of substituted 4-(thiophen-2-ylmethyl)-2H- phthalazin-1-ones as potent PARP-1 inhibitors. Preliminary biological evaluation indicated that most compounds possessed inhibitory potencies comparable to, or higher than AZD-2281. Among these compounds, 18q appeared to be the most notable one, which displayed an 8-fold improvement in enzymatic activity compared to AZD-2281. These efforts lay the foundation for our further investigation.