883731-17-7

Basic information

• Product Name: Adenosine, 2-(cyclopentyloxy)-5'-deoxy-3'-O-[(3,4-dichlorophenyl)methyl]-
• CAS NO: 883731-17-7
• Molecular Formula: C22H25Cl2N5O4
• Molecular Weight: 494.378
• Mol File: 883731-17-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Adenosine, 2-(cyclopentyloxy)-5'-deoxy-3'-O-[(3,4-dichlorophenyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Adenosine, 2-(cyclopentyloxy)-5'-deoxy-3'-O-[(3,4-dichlorophenyl)methyl]-(883731-17-7)
• EPA Substance Registry System: Adenosine, 2-(cyclopentyloxy)-5'-deoxy-3'-O-[(3,4-dichlorophenyl)methyl]-(883731-17-7)

Safety Data

• Hazardous Substances Data: 883731-17-7(Hazardous Substances Data)

Upstream product

• 146-77-0 2-Chloroadenosine 
• 6287-38-3 3,4-dichlorobenzaldehyde 
• 1344701-10-5 C₁₈H₂₄FN₅O₄ 
• 1344693-19-1 C₂₂H₂₃Cl₂N₅O₄ 
• 883731-83-7 2-chloro-9-[5-deoxy-5-fluoro-2,3-O-(1-methylethylidene)-β-D-ribofuranosyl]-9H-purin-6-amine 
• 53458-44-9 2-chloro-O^{2'_,O3'_{-isopropylidene-O}5'}-(toluene-4-sulfonyl)-adenosine 
• 24639-06-3 ((3aR,4R,6R,6aR)-6-(6-amino-2-chloro-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol 

Relevant articles and documents

Discovery of bacterial NAD+-dependent DNA ligase inhibitors: Optimization of antibacterial activity

Optimization of adenosine analog inhibitors of bacterial NAD +-dependent DNA ligase is discussed. Antibacterial activity against Streptococcus pneumoniae and Staphylococcus aureus was improved by modification of the 2-position substituent on the adenine ring and 3′- and 5′-substituents on the ribose. Compounds with log D values 1.5-2.5 maximized potency and maintained drug-like physical properties.