88382-49-4Relevant articles and documents
ARYLSULFANYL COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS
-
Page/Page column 58-59, (2008/06/13)
Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are also provided.
Kinetics of the reaction of sodium arylthiolates with nitro-carboxybenzyl halide derivatives
Hamed, Ezzat A.,El-Bardan, Ali A.,El-Mallah, Nabila M.
, p. 283 - 289 (2007/10/03)
The rate constants for the reactions of 4-halomethyl-3-nitrobenzoic acids, the nonnitro derivatives, and their ethyl esters with arylthiolates were measured at different temperatures. It was found that the retardation in rate constants compared to benzyl halides is due to the electrostatic repulsion between the electronegative substituents (COO- and/or NO2) in the substrates and thiolate ions Good correlations between log K2 values of the acids and carbon basicities of thiolates were found while log k2 values of the esters show good straight lines with Hammett a constants, pKa. and carbon basicities of arylthiolates.
Synthesis and antifolate properties of 10-alkyl-8,10-dideazaminopterins
DeGraw,Christie,Brown,Kelly,Kisliuk,Gaumont,Sirotnak
, p. 376 - 380 (2007/10/02)
The synthesis of 10-alkyl analogues of the potent antitumor agent 8,10-dideazaminopterin is described. Alkylation of appropriate α-alkyl homoterephthalate esters with 2,4-diamino-6-(bromomethyl)-8-deazapteridine afforded 10-alkyl-10-carboxy-4-amino-4-deox
