88398-78-1

Basic information

• Product Name: 1H-Pyrazole-4-carboxylic acid, 1-methyl-, ethyl ester
• Synonyms: 1H-Pyrazole-4-carboxylic acid, 1-methyl-, ethyl ester;1- Methyl-4-ethoxycarbonyl-5-hydroxypyrazol;Ethyl 5-hydroxy-1-Methyl-1H-pyrazole-4-carboxylate;5-Hydroxy-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester
• CAS NO: 88398-78-1
• Molecular Formula: C₇H₁₀N₂O₃
• Molecular Weight: 154
• Mol File: 88398-78-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 138-139 °C(Solv: ethanol (64-17-5); ethyl ether (60-29-7))
• Boiling Point: 268.078 °C at 760 mmHg
• Flash Point: 115.93 °C
• Appearance: /
• Density: 1.294 g/cm³
• Storage Temp.: 2-8°C
• PKA: 9.04±0.28(Predicted)
• CAS DataBase Reference: 1H-Pyrazole-4-carboxylic acid, 1-methyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole-4-carboxylic acid, 1-methyl-, ethyl ester(88398-78-1)
• EPA Substance Registry System: 1H-Pyrazole-4-carboxylic acid, 1-methyl-, ethyl ester(88398-78-1)

Safety Data

• Hazardous Substances Data: 88398-78-1(Hazardous Substances Data)

Usage

General Description

1H-Pyrazole-4-carboxylic acid, 1-methyl-, ethyl ester is a chemical compound with the molecular formula C7H9N3O2. It is an ethyl ester derivative of 1-methyl-1H-pyrazole-4-carboxylic acid. 1H-Pyrazole-4-carboxylic acid, 1-methyl-, ethyl ester is commonly used in pharmaceutical and agrochemical research as a building block for the synthesis of biologically active compounds. It is also used as a reagent in organic synthesis and in the preparation of various heterocyclic compounds. This chemical has potential applications in drug discovery and development due to its ability to modulate biological systems and exhibit specific pharmacological activities.

Upstream product

• 31037-02-2 ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate 
• 60-34-4 methylhydrazine 
• 7339-53-9 methyl hydrazine hydrochloride 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 

Downstream Products

• 321597-74-4 ethyl 5-benzyloxy-1-methylpyrazole-4-carboxylate 
• 56984-32-8 5-chloro-1-methyl-1H-pyrazole-4-carboxylic acid,ethyl ester 
• 88398-82-7 ethyl 5-(chlorosulfonyl)-1-methyl-1H-pyrazole-4-carboxylate 
• 88398-81-6 ethyl 1-methyl-5-sulfamoyl-1H-pyrazole-4-carboxylate 
• 33641-15-5 1-methyl-5-hydroxypyrazole 

Relevant articles and documents

Synthesis method of 1-methyl-5-hydroxy pyrazole

The invention relates to a synthesis method of 1-methyl-5-hydroxy pyrazole, which comprises the following steps of dropwisely adding tetrahydropyrrole into diethyl ethoxymethylene malonate at room temperature, and reacting at 15-80 DEG C for 2-6 hours to obtain a reaction solution A containing a compound represented by a formula (II), dropwise adding a methylhydrazine aqueous solution into the reaction solution A, and reacting at 15-80 DEG C for 2-6 hours to obtain a reaction solution B containing a compound shown as a formula (III), dropwise adding an acidic solution into the reaction solution B, and heating and refluxing for 4-8 hours at 90-120 DEG C after dropwise adding to obtain a reaction solution C containing a compound shown as a formula (IV), and carrying out post-treatment on thereaction solution C to obtain the target compound 1-methyl-5-hydroxy pyrazole. The synthesis method has the advantages of higher activity, higher reaction rate, better selectivity, higher total yield, cheap and accessible raw materials and simple post-treatment, and can obtain the solid 1-methyl-5-hydroxy pyrazole with higher purity.

Pyrazole ketone compound or its salt, preparation method thereof, and use of the herbicide composition (by machine translation)

This application pertains to the field of agricultural chemicals, in particular to a pyrazole ketone compound or its salt, preparation method, herbicidal composition and use. The ketone compounds states the pyrazole shown as formula I: In the formula, R 1 R 2 N representative containing substituted or unsubstituted 1-3 of the aza-3-8-membered nitrogen-containing heterocyclic base; or R 1, R 2 respectively represents hydrogen, C 1-8 alkyl etc.; R 3 representative hydrogen, C 1-4 alkyl, alkenyl, alkynyl, or unsubstituted C 1-4 alkyl substituted C 3-6 cycloalkyl; R 4 represents methyl, ethyl, n-propyl, isopropyl, cyclopropyl; X represents hydrogen, -S (O) n R 6, -R 7, containing substituted or unsubstituted 1-4 of the aza-3-8-membered heterocyclic group, wherein n representative 1, 2, 3, R 6 represents a substituted or unsubstituted alkyl or aryl, R 7 represents a substituted or unsubstituted alkyl, aryl, alkanoyl or sweet-smelling acyl. The present invention provides good efficacy of the pharmaceutical actives, easy to use, low cost, has good commercial value. (by machine translation)

PHOTOCHEMICAL SYNTHESIS OF 4-ETHOXYCARBONYL-5-HYDROXYPYRAZOLES

The photochemical decomposition of 4-ethoxycarbonyl-5-diazopyrazoles in tetrafluoroboric acid results in corresponding 4-ethoxycarbonyl-5-hydroxypyrazoles (V-VII).The irradiation of the diazocompound in dioxane, toluene or tetrahydrofurane proceeds with a reductive decomposition producing corresponding 4-ethoxycarbonylpyrazole (VIII) as the main photoproduct.