88404-22-2

Basic information

• Product Name: N-(tert-Butyloxy)carbonyl-L-thyroxine
• Synonyms: N-(tert-Butyloxy)carbonyl-L-thyroxine;(S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)propanoic acid
• CAS NO: 88404-22-2
• Molecular Formula: C20H19I4NO6
• Molecular Weight: 876.98584
• Product Categories: Amino Acids & Derivatives, Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 88404-22-2.mol
• Article Data: 12

Chemical Properties

• Melting Point: 212 °C(Solv: ethyl acetate (141-78-6))
• Boiling Point: 660.0±55.0 °C(Predicted)
• Appearance: /
• Density: 2.272±0.06 g/cm3(Predicted)
• Solubility: Chloroform, Dichloromethane, Methanol
• PKA: 2.78±0.10(Predicted)
• CAS DataBase Reference: N-(tert-Butyloxy)carbonyl-L-thyroxine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(tert-Butyloxy)carbonyl-L-thyroxine(88404-22-2)
• EPA Substance Registry System: N-(tert-Butyloxy)carbonyl-L-thyroxine(88404-22-2)

Safety Data

• Hazardous Substances Data: 88404-22-2(Hazardous Substances Data)

Usage

Description

N-(tert-Butyloxy)carbonyl-L-thyroxine is a synthetic derivative of L-thyroxine, a naturally occurring hormone in the human body. It is characterized by the presence of a tert-butyloxycarbonyl group attached to the nitrogen atom, which provides unique chemical and biological properties. N-(tert-Butyloxy)carbonyl-L-thyroxine is of interest in the field of analytical chemistry and biochemistry due to its potential applications in the development of biosensors and other diagnostic tools.

Uses

Used in Analytical Chemistry:
N-(tert-Butyloxy)carbonyl-L-thyroxine is used as a key component in the preparation of thyroxine (T4) analogue biosensors. These biosensors are designed for use on the BIAcore surface plasmon resonance instrument, a powerful analytical tool that enables real-time monitoring of biomolecular interactions.
Used in Biomedical Research:
In biomedical research, N-(tert-Butyloxy)carbonyl-L-thyroxine-based biosensors can be employed to study the binding kinetics and affinity of thyroxine and its analogues to specific receptors or other biomolecules. This information is crucial for understanding the mechanisms of thyroid hormone action and for the development of new therapeutic agents targeting the thyroid system.
Used in Pharmaceutical Industry:
The development of thyroxine analogue biosensors using N-(tert-Butyloxy)carbonyl-L-thyroxine can also benefit the pharmaceutical industry by providing a means to screen and optimize compounds with potential therapeutic effects on the thyroid gland. This can lead to the discovery of novel drugs for the treatment of thyroid-related disorders, such as hypothyroidism and hyperthyroidism.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 300-30-1 thyroxine 
• 3132-64-7 1,2-Epoxy-3-bromopropane 
• 51-48-9 L-thyroxine 
• 1431868-05-1 C₂₁H₂₃I₂NO₆ 
• 1016161-91-3 C₃₀H₄₃I₂NO₆Si 
• 128781-80-6 (S)-methyl 2-((tert-butoxycarbonyl)amino)-3-(4-hydroxy-3,5-diiodophenyl)propanoate 
• 4326-36-7 (S)-N-(tert-butoxycarbonyl)tyrosine methyl ester 
• 1080-06-4 L-Tyr-OMe 
• 60-18-4 L-tyrosine 
• 1431868-09-5 methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4-hydroxy-3,5-diaiodophenoxy)-3,5-diaiodophenyl)propanoate 

Relevant articles and documents

Novel derivatives of thyroid hormone and use of thereof

The present invention relates to: a thyroid hormone derivative or a pharmaceutically acceptable salt thereof; a pharmaceutical composition for the prevention or treatment of diseases of the brain and nervous system due to dopamine deficiency, containing the same as an active ingredient; and a method for treating diseases of the brain and nervous system caused by dopamine deficiency. The thyroid hormone derivative according to the present invention can promote the differentiation of neural progenitors into dopamine neurons like thyroid hormones, while lowering the risk of hyperthyroidism by repeated administration, and thus, can be useful for the prevention and treatment of diseases of the brain and nervous system due to dopamine deficiency, including Parkinsonandprime;s disease. A compound or a pharmaceutically acceptable salt thereof is represented by chemical formula 1.COPYRIGHT KIPO 2021

Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists, and formulations and uses thereof

Disclosed are methods of treating subjects having conditions related to angiogenesis including administering an effective amount of a polymeric Nanoparticle form of thyroid hormone agonist, partial agonist or an antagonist thereof, to promote or inhibit angiogenesis in the subject. Compositions of the polymeric forms of thyroid hormone, or thyroid hormone analogs, are also disclosed.

Uses of formulations of thyroid hormone antagonists and nanoparticulate forms thereof to increase chemosensivity and radiosensitivity in tumor or cancer cells

Disclosed are methods of increasing the chemosensitivity of normal and/or chemoresistant tumor or cancer cells using thyroid hormone antagonists and/or nanoparticulate or polymeric forms thereof. Also disclosed are methods of increasing radiosensitivity of normal and/or radioresistant tumor or cancer cells using thyroid hormone antagonists and/or nanoparticulate or polymeric forms thereof.