884331-11-7

Basic information

• Product Name: methanesulfonic acid 3-(2-{tert-butoxycarbonyl-[2-hydroxy-2-(3-hydroxy-phenyl)-ethyl]-amino}-propyl)-1H-indol-7-yl ester
• CAS NO: 884331-11-7
• Molecular Weight: 504.604
• Mol File: 884331-11-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methanesulfonic acid 3-(2-{tert-butoxycarbonyl-[2-hydroxy-2-(3-hydroxy-phenyl)-ethyl]-amino}-propyl)-1H-indol-7-yl ester(CAS DataBase Reference)
• NIST Chemistry Reference: methanesulfonic acid 3-(2-{tert-butoxycarbonyl-[2-hydroxy-2-(3-hydroxy-phenyl)-ethyl]-amino}-propyl)-1H-indol-7-yl ester(884331-11-7)
• EPA Substance Registry System: methanesulfonic acid 3-(2-{tert-butoxycarbonyl-[2-hydroxy-2-(3-hydroxy-phenyl)-ethyl]-amino}-propyl)-1H-indol-7-yl ester(884331-11-7)

Safety Data

• Hazardous Substances Data: 884331-11-7(Hazardous Substances Data)

Upstream product

• 884331-12-8 methanesulfonic acid 3-{2-[2-(3-benzyloxy-phenyl)-2-(tert-butyl-dimethyl-silanyloxy)-ethylamino]-propyl}-1H-indol-7-yl ester 
• 884330-84-1 (R)-1-(3-Benzyloxy-phenyl)-2-bromo-ethanol 
• 121-71-1 3-Hydroxyacetophenone 
• 19381-40-9 1-(3-(benzyloxy)phenyl)-2-bromoethanone 
• 34068-01-4 1-[3-(phenylmethoxy)phenyl]ethan-1-one 

Downstream Products

• 884331-33-3 benzenesulfonic acid 3-(2-{tert-butoxycarbonyl-[2-(7-methanesulfonyloxy-1H-indol-3-yl)-1-methyl-ethyl]-amino}-1-hydroxy-ethyl)-phenyl ester 

Relevant articles and documents

Tryptamine-based human β3-adrenergic receptor agonists. Part 3: Improved oral bioavailability via modification of the sulfonamide moiety

The continued SAR investigation of tryptamine-based human β3-adrenergic receptor (AR) agonists is reported. Prior efforts resulted in the identification of 2 as a potent β3-AR agonist. Further modification of the left side arylsulfonamide portion in 2 provided compounds with good cell permeability, which have potent agonistic activity for β3-AR. Cinnamylamine analog 16i exhibited an excellent agonistic profile in vitro and good oral bioavailability in rats.